Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4607347..4607965 Replicon chromosome
Accession NZ_CP063214
Organism Escherichia coli strain ERP001

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag IL987_RS22105 Protein ID WP_001291435.1
Coordinates 4607347..4607565 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag IL987_RS22110 Protein ID WP_000344800.1
Coordinates 4607591..4607965 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IL987_RS22070 4602634..4603206 + 573 WP_000779830.1 YbaY family lipoprotein -
IL987_RS22075 4603237..4603548 - 312 WP_000409908.1 MGMT family protein -
IL987_RS22085 4603927..4604280 + 354 WP_000878138.1 DUF1428 family protein -
IL987_RS22090 4604322..4605872 - 1551 WP_001298569.1 cyclic-guanylate-specific phosphodiesterase PdeB -
IL987_RS22095 4606036..4606506 - 471 WP_000136192.1 YlaC family protein -
IL987_RS22100 4606622..4607173 - 552 WP_000102539.1 maltose O-acetyltransferase -
IL987_RS22105 4607347..4607565 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
IL987_RS22110 4607591..4607965 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
IL987_RS22115 4608510..4611659 - 3150 WP_001132481.1 multidrug efflux RND transporter permease subunit -
IL987_RS22120 4611682..4612875 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T177728 WP_001291435.1 NZ_CP063214:c4607565-4607347 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T177728 NZ_CP083640:c3394475-3394372 [Enterobacter ludwigii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT177728 WP_000344800.1 NZ_CP063214:c4607965-4607591 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT177728 NZ_CP083640:3394358-3394510 [Enterobacter ludwigii]
GCTTTCAATCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCG
CTAAAAGTTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References