Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4114985..4115535 Replicon chromosome
Accession NZ_CP063214
Organism Escherichia coli strain ERP001

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag IL987_RS19855 Protein ID WP_001160966.1
Coordinates 4115221..4115535 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1NMQ0
Locus tag IL987_RS19850 Protein ID WP_000125568.1
Coordinates 4114985..4115218 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IL987_RS19825 4110058..4110345 + 288 WP_000203741.1 ferredoxin-like protein FixX -
IL987_RS19830 4110404..4111735 + 1332 WP_001183198.1 MFS transporter -
IL987_RS19835 4111843..4112373 + 531 WP_193579213.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
IL987_RS19840 4112366..4114228 + 1863 WP_000377109.1 glutathione-regulated potassium-efflux system protein KefC -
IL987_RS19845 4114420..4114899 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
IL987_RS19850 4114985..4115218 + 234 WP_000125568.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
IL987_RS19855 4115221..4115535 + 315 WP_001160966.1 CcdB family protein Toxin
IL987_RS19860 4115532..4116380 - 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
IL987_RS19865 4116387..4116764 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
IL987_RS19870 4116767..4117588 - 822 WP_001065363.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
IL987_RS19875 4117585..4118574 - 990 WP_000241225.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
IL987_RS19880 4118574..4119860 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T177726 WP_001160966.1 NZ_CP063214:4115221-4115535 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T177726 NZ_CP083640:1047263-1047502 [Enterobacter ludwigii]
ATGACTTATGAACTCGTATTTGATCCGAGGGCGTTCAAGGAGTGGACCAGGCTGGGTGATACCGTAAAAAATCAGTTTAA
GAAGAAGCTTGCGAACGTGTTGGTGAACCCCAGGGTTGAATCGGCTCGCCTGCATGGCCTGCCTGATTGCGACAAGATAA
AACTCAGATCCCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTGACGGTATGTGTTATTGCTATCGGTTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8560.55 Da        Isoelectric Point: 5.8062

>AT177726 WP_000125568.1 NZ_CP063214:4114985-4115218 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENTEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT177726 NZ_CP083640:1047031-1047273 [Enterobacter ludwigii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTTGAAAAACTCAATATCACGCC
AACGGAAGCCGTTCGGTTACTGTTTCAGTACGTTGCGGAGACGGGGCGTATGCCGGTGAAAACGGTCACTGTTAGCGACA
GTGAAGATGAACTCATACAGACAGTCCGGGAGCGGTTGGCTAATCCGCAAAAAGGAATTAAGGTTAGGCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G815

Antitoxin

Source ID Structure
AlphaFold DB A0A829GEF2

References