Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3699974..3700799 Replicon chromosome
Accession NZ_CP063214
Organism Escherichia coli strain ERP001

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag IL987_RS17865 Protein ID WP_089569554.1
Coordinates 3699974..3700348 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag IL987_RS17870 Protein ID WP_137467678.1
Coordinates 3700437..3700799 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IL987_RS17845 3696534..3698072 - 1539 WP_042093790.1 lysine decarboxylation/transport transcriptional activator CadC -
IL987_RS17850 3698907..3699467 - 561 Protein_3485 DUF4942 domain-containing protein -
IL987_RS17855 3699552..3699749 - 198 WP_193579435.1 hypothetical protein -
IL987_RS17860 3699777..3699977 - 201 Protein_3487 hypothetical protein -
IL987_RS17865 3699974..3700348 - 375 WP_089569554.1 type IV toxin-antitoxin system toxin CbtA Toxin
IL987_RS17870 3700437..3700799 - 363 WP_137467678.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IL987_RS17875 3700873..3701094 - 222 WP_000692323.1 DUF987 domain-containing protein -
IL987_RS17880 3701163..3701639 - 477 WP_001186181.1 RadC family protein -
IL987_RS17885 3701655..3702140 - 486 WP_193579182.1 antirestriction protein -
IL987_RS17890 3702232..3703050 - 819 WP_001234749.1 DUF945 domain-containing protein -
IL987_RS17895 3703141..3703374 - 234 WP_001278287.1 DUF905 family protein -
IL987_RS17900 3703380..3704057 - 678 WP_001097301.1 hypothetical protein -
IL987_RS17905 3704205..3704885 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3688721..3719721 31000


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(16-115)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13800.77 Da        Isoelectric Point: 6.4612

>T177721 WP_089569554.1 NZ_CP063214:c3700348-3699974 [Escherichia coli]
MKTLPVLPGQAASSRLSPVEIWQILLSRLLDQHYGLTLDDTPFADERVIEQHIEAGISLCDAVNFLVEKYTLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T177721 NZ_CP083638:c4317216-4316875 [Escherichia fergusonii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGTCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACTGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTATGCAAATTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTAATTGC
GGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13380.20 Da        Isoelectric Point: 6.4648

>AT177721 WP_137467678.1 NZ_CP063214:c3700799-3700437 [Escherichia coli]
VSDTLPGTTHPDNNRPWWGLPCTVMPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSGEL
SPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKT

Download         Length: 363 bp

>AT177721 NZ_CP083638:4317211-4317287 [Escherichia fergusonii]
AGTCATAACTGCTATTCTCCTGAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References