Detailed information of TA system TA177699

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/PHD-RelE
• Location: 2260614..2261134
• Replicon: chromosome
• Accession: NZ_CP063213
• Organism: Trueperella sp. 19M2397 strain 15A0121

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: INS88_RS10300
• Protein ID: WP_193326695.1
• Coordinates: 2260874..2261134 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: INS88_RS10295
• Protein ID: WP_193326696.1
• Coordinates: 2260614..2260877 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INS88_RS10285	2258643..2259167	+	525	WP_197551144.1	lipocalin family protein	-
INS88_RS10290	2259250..2260512	-	1263	WP_197551824.1	methyltransferase domain-containing protein	-
INS88_RS10295	2260614..2260877	+	264	WP_193326696.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
INS88_RS10300	2260874..2261134	+	261	WP_193326695.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
INS88_RS10305	2261139..2263802	-	2664	WP_197551825.1	ATP-dependent helicase HrpB	-
INS88_RS10310	2263799..2264419	-	621	WP_197551145.1	TetR/AcrR family transcriptional regulator	-
INS88_RS10315	2264541..2265218	-	678	WP_197551146.1	TrkA family potassium uptake protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (7-71)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9957.48 Da
• Isoelectric Point: 10.5719

>T177699 WP_193326695.1 NZ_CP063213:2260874-2261134 [Trueperella sp. 19M2397]
VSYRVELTTAAARQIKKLPHEARGRILDALEKLADDPRPRGAKKLVGEQNAWRIRLGDYRIIYDIFDDILTATIVRAGHR
REIYRS

Nucleotide

• Length: 261 bp

>T177699 NZ_CP083631:4648782-4649192 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCTCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCACTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGAATGCTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGGGACCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9524.68 Da
• Isoelectric Point: 4.6412

>AT177699 WP_193326696.1 NZ_CP063213:2260614-2260877 [Trueperella sp. 19M2397]
MNTITSEVSTRELRSQLSDVLGRAMYAGERIGVTRHGKLAAVVVSVADLEALEEFEMAQDVAAYRAARAEDDGGRVSLDE
LRRTLTQ

Nucleotide

• Length: 264 bp

>AT177699 NZ_CP083631:4648535-4648801 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCTCGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TATTCAACTGGCTGATGAACCATGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA