Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 44356..44966 Replicon chromosome
Accession NZ_CP063213
Organism Trueperella sp. 19M2397 strain 15A0121

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag INS88_RS00215 Protein ID WP_197551204.1
Coordinates 44595..44966 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag INS88_RS00210 Protein ID WP_197551203.1
Coordinates 44356..44598 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INS88_RS00190 39752..40306 - 555 WP_193326614.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
INS88_RS00195 40306..41637 - 1332 WP_197551201.1 DUF1624 domain-containing protein -
INS88_RS00200 41794..42759 + 966 WP_193326612.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
INS88_RS00205 42935..44206 - 1272 WP_197551202.1 dicarboxylate/amino acid:cation symporter -
INS88_RS00210 44356..44598 + 243 WP_197551203.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
INS88_RS00215 44595..44966 + 372 WP_197551204.1 type II toxin-antitoxin system VapC family toxin Toxin
INS88_RS00220 45013..45585 + 573 WP_197551205.1 low molecular weight phosphotyrosine protein phosphatase -
INS88_RS00225 45612..46400 - 789 WP_193326607.1 hypothetical protein -
INS88_RS00230 46555..47883 - 1329 WP_197551206.1 sugar ABC transporter substrate-binding protein -
INS88_RS00235 48053..48898 - 846 WP_197551207.1 carbohydrate ABC transporter permease -
INS88_RS00240 48901..49737 - 837 WP_197551733.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-119)

Antitoxin

Antitoxin VapB-like

(4-79)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13395.29 Da        Isoelectric Point: 4.5242

>T177698 WP_197551204.1 NZ_CP063213:44595-44966 [Trueperella sp. 19M2397]
MIVDTSALVAVAYREPGYERITDLLFARNRSKMSVASVLELQLVLRSSELADELIEIFNVDPVGIDVDQLRVARHAAQRF
GKGTGSKAGLNYGDCFSYALAMTAGEPLLFVGEDFTHTDVVVA

Download         Length: 372 bp

>T177698 NZ_CP083631:c3322282-3321998 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCTTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCGACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGGGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9102.22 Da        Isoelectric Point: 4.8660

>AT177698 WP_197551203.1 NZ_CP063213:44356-44598 [Trueperella sp. 19M2397]
MPTMNIKDEDVYNAARQLAQLRGTSMTGAVRSAVEEALDAEIKRRERGRLRLAELQDRIAQAAEPRLDESDLYDDRGMPR

Download         Length: 243 bp

>AT177698 NZ_CP083631:c3322514-3322272 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTGCGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACTGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References