Detailed information of TA system TA177692

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 924041..925566
• Replicon: chromosome
• Accession: NZ_CP063202
• Organism: Erythrobacter sp. SCSIO 43205

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: -
• Locus tag: INR77_RS04295
• Protein ID: WP_255573931.1
• Coordinates: 924041..925312 (-)
• Length: 424 a.a.

Antitoxin (Protein)

• Gene name: HipB1
• Uniprot ID: -
• Locus tag: INR77_RS04300
• Protein ID: WP_223072696.1
• Coordinates: 925309..925566 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INR77_RS04285 (INR77_04285)	919912..921216	+	1305	WP_223072693.1	amidohydrolase family protein	-
INR77_RS04290 (INR77_04290)	921376..923163	-	1788	WP_223072694.1	recombinase family protein	-
INR77_RS04295 (INR77_04295)	924041..925312	-	1272	WP_255573931.1	type II toxin-antitoxin system HipA family toxin	Toxin
INR77_RS04300 (INR77_04300)	925309..925566	-	258	WP_223072696.1	type II toxin-antitoxin system Y4mF family antitoxin	Antitoxin
INR77_RS04305 (INR77_04305)	925956..926474	-	519	WP_223072697.1	MarR family winged helix-turn-helix transcriptional regulator	-
INR77_RS04310 (INR77_04310)	927074..928822	+	1749	WP_223072698.1	ABC transporter ATP-binding protein	-
INR77_RS04315 (INR77_04315)	928822..929856	+	1035	WP_223072699.1	HlyD family efflux transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	gmd / fcl	880059..1005846	125787

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (9-107)

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-62)

Sequences

Toxin

Protein

• Length: 424 a.a.
• Molecular weight: 45576.34 Da
• Isoelectric Point: 6.4217

>T177692 WP_255573931.1 NZ_CP063202:c925312-924041 [Erythrobacter sp. SCSIO 43205]
VTLPIPDTLAVWWGERQAGELSIDKGGAMHFAYSSGWLVDEKAPALSQAMPKREEPFGDQTCKAVFGGLLPEESQRTAIA
RALGISPDNPFRLLEALGGDVAGALSLLAQGEKPLQAYSKTAPQSLQEGELAELLSRLPSVPMLAGEGGARLSLAGAQSK
LPVVLTVEGGIAIPRPGEPSTHLIKPEPDRFVGLAANEAFCLALARKVGIDAAYAEWREVAGKPLLLVERYDRIMLDGKT
HRLHQEDFAQALGVPSNRKYAAEGGPTFHDSFALLRSAATRPAREVLKLADAAIFNLIIGNADAHAKNYSLLSLENSEVI
LAPLYDLVATHMWKELSPKLAMRFGRAANLEDFNEGNVARFAQEAGLGMPYIRRRIAELAQTIIHETEKGVAVPGCTHKD
SLDKIAKCTVERAKVVECRLSLG

Nucleotide

• Length: 1272 bp

>T177692 NZ_CP083630:3283860-3284276 [Leclercia adecarboxylata]
GTGATCAAGACCTATATGCTGGACACCAACATTTGCTCGTTCATCATGCGTGAGCAGCCGGAAGCTGTCATTAAACGGCT
GGAGCAGGCAGTGCTGCGGAATCACCGCATCGTGGTTTCGGCCATTACTTATGCAGAGATGCGTTTCGGTGCGATCGGAA
AGAAGGCATCTCCCCGCCACGGCCTGCTTGTCGAAGCTTTCTGCGCCCGCCTCGATGCAATCCTCGCCTGGGACCGCGCC
GCGGTGGACGCAACCACGGAGATTAAGGCCGCACTGACTGCGGCCGGGACGCCAATCGGTCCGAACGATACGGCGATCGC
CGGGCATGCCATCGCCGCCGGCGCAGTGCTGGTAACGAACAATGTACGTGAGTTTGAGCGTGTGCCTGGCCTTGTCCTGG
AAGACTGGGCTAACTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9151.81 Da
• Isoelectric Point: 9.1838

>AT177692 WP_223072696.1 NZ_CP063202:c925566-925309 [Erythrobacter sp. SCSIO 43205]
MLDVAAIGQIIREERKELGLRQDELAAASGVGLRFLVELERGKPTVQMGKVLDVLAALGCQIQIKRPGAMAIAGQVDKPK
KDKAE

Nucleotide

• Length: 258 bp

>AT177692 NZ_CP083630:3283633-3283863 [Leclercia adecarboxylata]
ATGAGAACCGTATCGATATTCAAAAACGGCAACAATCGCGCTATCCGTCTGCCCCGCGACCTGGATTTTGAGGGAGTGAG
CGAACTGGAAATCGTCCGGGAAGGTGACAGCATCATCCTTCGTCCCGTTCGTCCAACATGGGGTTCGTTTACTCAGCTCG
AAAAAGCCGACTCAGACTTTATGTCCGAACGTGGGGACGTCGTCAGCGATGAAGGACGGTTTGACTTGTGA