Detailed information of TA system TA177691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 1160847..1162206
• Replicon: chromosome
• Accession: NZ_CP063200
• Organism: Vibrio sp. SCSIO 43132

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: INR79_RS23405
• Protein ID: WP_223097146.1
• Coordinates: 1161253..1162206 (+)
• Length: 318 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: INR79_RS23400
• Protein ID: WP_022602507.1
• Coordinates: 1160847..1161251 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INR79_RS23375 (INR79_23375)	1155881..1157230	-	1350	WP_022613282.1	GGDEF domain-containing protein	-
INR79_RS23380 (INR79_23380)	1157227..1158228	-	1002	WP_223097141.1	ABC transporter substrate-binding protein	-
INR79_RS23385 (INR79_23385)	1158729..1159904	+	1176	WP_223097142.1	MFS transporter	-
INR79_RS23390 (INR79_23390)	1159972..1160187	+	216	WP_004405721.1	DUF3820 family protein	-
INR79_RS23395 (INR79_23395)	1160227..1160469	+	243	WP_223097144.1	hypothetical protein	-
INR79_RS23400 (INR79_23400)	1160847..1161251	+	405	WP_022602507.1	DUF6088 family protein	Antitoxin
INR79_RS23405 (INR79_23405)	1161253..1162206	+	954	WP_223097146.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
INR79_RS28180	1162244..1162885	-	642	WP_262415414.1	transposase	-
INR79_RS28185	1162915..1163373	-	459	WP_262415415.1	transposase	-
INR79_RS28190	1163400..1163666	-	267	WP_262415416.1	DUF6444 domain-containing protein	-
INR79_RS28195	1163814..1164023	-	210	Protein_1056	transposase	-
INR79_RS23415 (INR79_23415)	1164354..1166066	-	1713	WP_223097148.1	metallophosphoesterase	-
INR79_RS23420 (INR79_23420)	1166069..1167112	-	1044	WP_223097149.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1160227..1168802	8575

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (37-304)

Antitoxin

• Protein of unknown function DUF6088 (9-129)

Sequences

Toxin

Protein

• Length: 318 a.a.
• Molecular weight: 36546.09 Da
• Isoelectric Point: 4.8442

>T177691 WP_223097146.1 NZ_CP063200:1161253-1162206 [Vibrio sp. SCSIO 43132]
MEKLKQQFLEVSDALELGNPAIIEKDYWVVALLSELAKVKADSHQMVFSGGTALAKSNVKILRMSEDVDIKLIPKPAFNE
LSRAKKKAARKICINEIEQIITQSKLFTIEERTVNDEFRYVEFEFRYPQQFSQSPCLRPIIKLELMETIPLLDVEPRNIQ
SLVAELYKQPQEVSAFDCISIHATLVEKVISMLRRTMSVKRDAQRKDDATLVRHIYDVYCILKTEEQTESLDLEALTPLF
KTVLEEDIERFGSQHAEFVANPKQELQLGLQEIEENPAFHQRFQDFVTPMVFSAEPHDFDTCFASFKRIAESLIEAI

Nucleotide

• Length: 954 bp

>T177691 NZ_CP083630:2945395-2945613 [Leclercia adecarboxylata]
ATGTCTGATAAACCCTTAACCAAGACAGATTATTTGATGCGTTTGCGACGCTGTCAGTCAATTGACACCCTTGAACGTGT
GATTGAGAAAAATAAATACGAGCTTTCTGATAATGAGTTAGCAGTATTCTATTCTGCAGCCGATCATCGTCTGGCTGAAC
TCACTATGAATAAGCTGTATGATAAAATTCCGACAGCCGTGTGGAAGTTTGTACGCTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15192.48 Da
• Isoelectric Point: 10.6056

>AT177691 WP_022602507.1 NZ_CP063200:1160847-1161251 [Vibrio sp. SCSIO 43132]
MTAVDRVYQKIKRSRRYVFERKDFDGFASYDQIGRALRQLVKQGELIKLGYGLYTKARINSLTGKPMPTNPGGSDALMRE
ILKMKGIDFEIDSLSLQSLSGESTQIPSSVQYSWNPKQFNRKLVVGNRVLNSPS

Nucleotide

• Length: 405 bp

>AT177691 NZ_CP083630:2944994-2945386 [Leclercia adecarboxylata]
ATGGACGAATACTCGCCTAAAAGGCAAGATATTGCACAGTTGAAATTCCTTTGTGAATCCCTGTACCATGACTGCCTTTC
CAATCTCGATGAAAGCAACCATGGCTGGGTCAATGACCCTACTTCTGCCATTAATTTGCAGTTAAACGAGTTGATTGAGC
ATATAGCAACCTTCGCGCTTAATTATAAAATTAAGTATAACGAAGATAATAAGTTGATTGAGCAAATTGACGAATACCTG
GATGACACTTTTATGTTATTCAGTAGCTACGGCATTAATGCACAGGATTTGCAAAAATGGCGTAAATCGGGCAATCGGCT
TTTTCGTTGTTTTGTCAATGCAAGCAAGGCTAACCCGTTAGCTTCGCCAGTTAAAATTATTACAAACAATTAG