Detailed information of TA system TA177690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 173110..173669
• Replicon: chromosome
• Accession: NZ_CP063200
• Organism: Vibrio sp. SCSIO 43132

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U4DSV3
• Locus tag: INR79_RS18950
• Protein ID: WP_004404011.1
• Coordinates: 173391..173669 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U4DQE1
• Locus tag: INR79_RS18945
• Protein ID: WP_004404015.1
• Coordinates: 173110..173394 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INR79_RS18925 (INR79_18925)	168992..170026	+	1035	WP_223098764.1	iron ABC transporter permease	-
INR79_RS18930 (INR79_18930)	170023..171000	+	978	WP_223098766.1	iron chelate uptake ABC transporter family permease subunit	-
INR79_RS18935 (INR79_18935)	171005..171802	+	798	WP_080927995.1	ATP-binding cassette domain-containing protein	-
INR79_RS18940 (INR79_18940)	172053..172886	+	834	WP_223098769.1	inositol monophosphatase	-
INR79_RS18945 (INR79_18945)	173110..173394	+	285	WP_004404015.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
INR79_RS18950 (INR79_18950)	173391..173669	+	279	WP_004404011.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
INR79_RS18955 (INR79_18955)	173687..173995	-	309	WP_223098773.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
INR79_RS18960 (INR79_18960)	174076..174705	-	630	WP_262415472.1	DUF998 domain-containing protein	-
INR79_RS18965 (INR79_18965)	174873..175628	-	756	WP_004404003.1	uroporphyrinogen-III C-methyltransferase	-
INR79_RS18970 (INR79_18970)	175681..176490	-	810	WP_004403999.1	formate/nitrite transporter family protein	-
INR79_RS18975 (INR79_18975)	176602..176934	-	333	WP_004403996.1	nitrite reductase small subunit NirD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-72)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10837.54 Da
• Isoelectric Point: 4.4400

>T177690 WP_004404011.1 NZ_CP063200:173391-173669 [Vibrio sp. SCSIO 43132]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDSLIEAKVENLLEQPLMGVQRNGIRGRLLIIPEVSIIVPYWVEGEVIRIL
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T177690 NZ_CP083630:2884286-2884648 [Leclercia adecarboxylata]
ATGTGGGAAGTCGAAACAACGGATACGTTTGACAAGTGGTTTAACCACCAGACACAAGCCTTGAAAGAAGATGTCCTGGC
TATAATGCATATCCTCTCAGAGTACGGTCCACAGTTGGGCCGTCCCTGGGTCGATACAGTTAAAAACTCACATTACGCGA
ATATGAAAGAGCTACGCATTCAGCATGCAGGGGATCCGGTTCGTGCTTTTTTTGCCTTCGATCCTGTTCGTAAAGCCATA
ATTTTATGTGCTGGAAATAAGACGGGAAAAAATGAAAAGCGATTCTATAAAGATATGATCACCATGGCTGATGCTGAATT
CAGCGATTATCTGGCGAGTAAGGAGGCCGAATGGCTACGTTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11022.34 Da
• Isoelectric Point: 8.0517

>AT177690 WP_004404015.1 NZ_CP063200:173110-173394 [Vibrio sp. SCSIO 43132]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKLDSGKSVFVEHESAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT177690 NZ_CP083630:2884636-2884935 [Leclercia adecarboxylata]
ATGGCTACGTTAAAAGAACTCATGGCCCAGCAGAGCCAGGAAAGTCAGGAGCGAATTGCCGCTAAAGTTGAGGATCTGCG
CATTATTGTCGCGCTCAACCAGCTCCGGGAAGAACTCAACATATCGCAAACTGAACTTGCTGCCGCGATGGGGGTTAAAC
AGCCTACCGTTGCGAAAATTGAGCAACCGGATAATGATCCGCGTCTTTCTACGCTTAAACGCTATGTTACGGCATTAGGG
GGTGAAGTGAGTATTGATGTCATTCTGCCCACCGGGAAGCGGATGGCGTTTCATTTTTGA

Structures

Toxin

• AlphaFold DB: U4DSV3

Antitoxin

• AlphaFold DB: U4DQE1