Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 2038446..2039070 Replicon chromosome
Accession NZ_CP063198
Organism Streptococcus agalactiae CJB111

Toxin (Protein)


Gene name parE Uniprot ID A0A076ZDW1
Locus tag ID870_RS10230 Protein ID WP_000253103.1
Coordinates 2038446..2038793 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A076YVN5
Locus tag ID870_RS10235 Protein ID WP_000543070.1
Coordinates 2038783..2039070 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ID870_RS10210 2034161..2034517 - 357 WP_000105934.1 DUF1304 domain-containing protein -
ID870_RS10215 2034584..2036902 - 2319 WP_000883414.1 YhgE/Pip domain-containing protein -
ID870_RS10220 2037041..2037580 + 540 WP_000245858.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
ID870_RS10225 2037666..2037962 - 297 WP_001052249.1 DUF4298 domain-containing protein -
ID870_RS10230 2038446..2038793 - 348 WP_000253103.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ID870_RS10235 2038783..2039070 - 288 WP_000543070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ID870_RS10240 2039139..2039516 - 378 WP_000038826.1 DUF1492 domain-containing protein -
ID870_RS10245 2039491..2039643 - 153 Protein_1947 DUF1492 domain-containing protein -
ID870_RS10250 2039650..2040138 - 489 WP_000891151.1 hypothetical protein -
ID870_RS10255 2040211..2040768 - 558 WP_001258765.1 hypothetical protein -
ID870_RS10260 2040926..2041099 - 174 WP_000694573.1 hypothetical protein -
ID870_RS10265 2041096..2041353 - 258 WP_001069293.1 hypothetical protein -
ID870_RS10270 2041646..2043040 - 1395 WP_000656430.1 hypothetical protein -
ID870_RS10275 2043052..2043909 - 858 WP_001029296.1 primase alpha helix C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2037666..2067246 29580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(12-108)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-63)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13333.09 Da        Isoelectric Point: 5.1643

>T177689 WP_000253103.1 NZ_CP063198:c2038793-2038446 [Streptococcus agalactiae CJB111]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Download         Length: 348 bp

>T177689 NZ_CP083630:1711229-1712539 [Leclercia adecarboxylata]
ATGCGCGCACAACGACTGACTGTTGCGATGAATGGCGACGTTGTAGGTACCCTGCATCGTGACGGCAGCGGGGCGATGTC
CTTCCAGTATGCCCCGGAGTGGCTGGCCGAGCCGGGTTCGCGCGCGATTTCGCTCTCTTTACCACTACAGCACGGCAGGA
TCAGAGGCGCGCAGGTCTTTAATTTCTTCAGTAATCTGCTGCCTGACTCCGAAGCGATTATTGCCCGCATGCAGGCCCGA
TTCCAGGTTGAAACCGCTCATCCCTTTGATCTGCTGGCCAGTGTCGGGCGTGACTGTGTGGGTGCCATTCAGCTCTATCC
GCCGGGACAGGAGATCCCCCCGGTAACCGATATCGTGGCCGAACCGCTGGATGACGATCAGATTGCCGCGCTGCTCGACG
GGTATCAGATGGCACCGCTGGGGATGACCGAGGAGGATGCCGACTTTCGCATTTCGCTGGCCGGCGCGCAGGAAAAGACG
GCGCTGCTATGGTACCAGGCACGCTGGCAGCGGCCCCAGGGTAGCACCCCAACCAGTCACATCTTTAAGCTGCCGATCGG
CAGAATAGAACAAAACAATATCGACCTGAGCGAAAGTTGTGAAAACGAATGGCTGTGTTTGCGCATTGCCAAAGCCTTTG
GTTTCCCAGTGGCACAGGCGGAGATGGCAACCTTTGGCCGCAAGAAAGTGCTGATTATCGAGCGTTTCGACCGTCGTTGG
GCCAGCAGCGGCTGGCTGATGCGTCTGCCGCAGGAAGATTTTTGCCAGGCCCTGGGCGTGTCGCCAGCGCTGAAATATGA
ATCTCACGGTGGTCCCGGGATTGCCGACGCCATGAAGCTGCTGCTCGGTTCCCGCCTGGCGGGGCAGGATCGCGAGCTGT
TCTTTAAGGCGCAGATCCTGTTCTGGATGCTGGCCGCCATTGATGGTCACGGGAAGAATTTCAGCCTGTTTATCGAGCCG
GATTCCGCCTTTCGCATGGCCCCGCTGTACGACGTGATTTCCGCGTTTCCGCTGTTCGACGCAGGGGGGATCCCGGTCAA
AAAAGCGAAGATGGCGATGGCGTTACAGGGCAAGAACCGGCAGTACCATTTTGCGATGATCCAACCGCGTCACTTTATTA
GCACCGCTGCTTTTGCAGGTTATTCCCAGGAGGCCGCTCGCCGTTTGCTGACTGAGATGGCGGAGCGAACAGACGACGTG
ATTGCCTCCGTCAGGGCAGAATTGCCACCGGATTTCCCCGCGCAGGTCAGTGAGGCCATTTTTAAGGGGTTAGCCAGCCA
GGCGGCAAGAATAGGGCGGTTCGTGAGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10605.98 Da        Isoelectric Point: 4.8430

>AT177689 WP_000543070.1 NZ_CP063198:c2039070-2038783 [Streptococcus agalactiae CJB111]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Download         Length: 288 bp

>AT177689 NZ_CP083630:1710974-1711225 [Leclercia adecarboxylata]
ATGAAAGTTACATCGGCAGACGCACTGGCTCAGGCTGTCCGGGATCAGCGTAAGGTCAATAAGTTAACCCAAACGGCAAC
GGCTGAACAGGTGGGGATTAAACAAACCACGGTATCGGAATTCGAGAACAAACCAGGCTCTACCAAACTAGAAACCTTGT
TCAAAATCCTCTCGGCGCTGGATCTGGAGCTGCACGTGGTGAAACGAGGCGGCACGTTGCCGGATAACAATGCCTGGAAG
AAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A076ZDW1

Antitoxin

Source ID Structure
AlphaFold DB A0A076YVN5

References