Detailed information of TA system TA177686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2167863..2168649
• Replicon: chromosome
• Accession: NZ_CP063194
• Organism: Corynebacterium jeddahense strain DSM 45997

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: CJEDD_RS10550
• Protein ID: WP_198132972.1
• Coordinates: 2167863..2168291 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: CJEDD_RS10555
• Protein ID: WP_198132971.1
• Coordinates: 2168365..2168649 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CJEDD_RS10545 (CJEDD_10410)	2164011..2167859	+	3849	WP_273657516.1	non-ribosomal peptide synthetase	-
CJEDD_RS10550 (CJEDD_10415)	2167863..2168291	-	429	WP_198132972.1	GNAT family N-acetyltransferase	Toxin
CJEDD_RS10555 (CJEDD_10420)	2168365..2168649	-	285	WP_198132971.1	DUF1778 domain-containing protein	Antitoxin
CJEDD_RS10560 (CJEDD_10425)	2168773..2169609	-	837	WP_042406052.1	hypothetical protein	-
CJEDD_RS10565 (CJEDD_10430)	2169787..2170512	-	726	WP_273657517.1	hypothetical protein	-
CJEDD_RS10570 (CJEDD_10435)	2170597..2171055	-	459	WP_157034427.1	hypothetical protein	-
CJEDD_RS10575 (CJEDD_10440)	2171314..2171637	+	324	WP_074432493.1	helix-turn-helix transcriptional regulator	-
CJEDD_RS10580 (CJEDD_10445)	2172223..2172915	-	693	WP_042406048.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2153290..2180495	27205

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (14-115)

Antitoxin

• Vibrio phage ICP1, Orf50 (7-78)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15811.33 Da
• Isoelectric Point: 8.7079

>T177686 WP_198132972.1 NZ_CP063194:c2168291-2167863 [Corynebacterium jeddahense]
MDVWFHRYALQNQRVKNCVVYVSTWNERVAGYYAICTGGLDKLTAPGSFAHRRPDPIPVIILARLAVDGNAQGRGVGKAL
LRDALARCFTAAEVIGVAAVVVHALDQQAKDFYLRHADFQELPGEPLHLLLPMKGIERFVRE

Nucleotide

• Length: 429 bp

>T177686 NZ_CP083630:1077539-1078024 [Leclercia adecarboxylata]
GTGGGACATGTAACAGCACCAGAACCTCTGTCCGCTTTTCATCAGGTGGCTGAGTTCGTGAGCGGTGAAACTGTGCTCGA
TGACTGGTTAAAGCAGAAAGGCCTAAAAAACCAGGCTCTCGGAGCGGCCAGAACGTTTGTGGTATGTAAGAAAGATACGA
AGCAAATAGCCGGCTTTTACTCTCTGGCCACCGGGAGCGTCAATCATACTGAAGCGACAGGGAATCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGCCTTGCTGTCGATCTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACATTGTTCCTCAGACTTCCT
CAATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10790.19 Da
• Isoelectric Point: 4.5854

>AT177686 WP_198132971.1 NZ_CP063194:c2168649-2168365 [Corynebacterium jeddahense]
VTVKDRRLNLRTTALQDDRLRQAAEAMNKSVSEFVLESAVERAEMVLADQRWFVLSEENFSRVEQLLERPADLAKLAELF
AADSPFGKEFDFGR

Nucleotide

• Length: 285 bp

>AT177686 NZ_CP083630:1077285-1077551 [Leclercia adecarboxylata]
ATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATAGATGCGGCTGCGGAAATCCTCCA
CAAGTCACGTACAGATTTCATTCTTGAAATGGCCTGTCAGGCTGCCGAGAATGTGATACTCGATCGCCGGGTATTTAACT
TTAACGATGAGCAATATGCGGAGTTCATCGATATGCTTGATGCACCGGTCGCAGATGATCCCATTATCGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACATGTAA