Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpK-mazE/MazF(toxin)
Location 3955111..3955697 Replicon chromosome
Accession NZ_CP063169
Organism Haloactinobacterium sp. RN3S43

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag IM660_RS17640 Protein ID WP_193497071.1
Coordinates 3955111..3955455 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag IM660_RS17645 Protein ID WP_159618118.1
Coordinates 3955452..3955697 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM660_RS17620 3950236..3951297 - 1062 WP_193497068.1 ABC transporter ATP-binding protein -
IM660_RS17625 3951285..3952844 - 1560 WP_210769170.1 ABC transporter permease subunit -
IM660_RS17630 3952898..3953980 - 1083 WP_193497070.1 iron ABC transporter substrate-binding protein -
IM660_RS17635 3954628..3955047 + 420 WP_193499504.1 MerR family transcriptional regulator -
IM660_RS17640 3955111..3955455 - 345 WP_193497071.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IM660_RS17645 3955452..3955697 - 246 WP_159618118.1 ribbon-helix-helix protein, CopG family Antitoxin
IM660_RS17650 3955730..3956911 - 1182 WP_193497072.1 acetyl-CoA C-acyltransferase -
IM660_RS17655 3956908..3957567 - 660 WP_193497073.1 CoA transferase subunit B -
IM660_RS17660 3957567..3958373 - 807 WP_193497074.1 CoA transferase subunit A -
IM660_RS17665 3958548..3959546 + 999 WP_210769015.1 nucleoside hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-33)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12168.18 Da        Isoelectric Point: 8.7387

>T177683 WP_193497071.1 NZ_CP063169:c3955455-3955111 [Haloactinobacterium sp. RN3S43]
VIARGSVVWVDFGTPRGSEPAKRRPAVVLQEDWLIESAISTVIVVPMTSNLKLEVFPGNVRIPALASSLDRDSVAVVSQV
GPIDRGFLEPHPIGRLPGYLMTQVAGGVRLVTGI

Download         Length: 345 bp

>T177683 NZ_CP083630:c240801-240472 [Leclercia adecarboxylata]
ATGAAACCTCAACCTGCAACAACTTCGCGGGCGGCGAAGCCATGCCTGTCACCTGTGGCTGTCTGGCAAATGCTGCTGAC
CCGACTGCTCGAAAAACACTATGGCCTGACGCTAAACGACACCCCGTTCAGTGATGAAACCGTGATTCAGGAACACATTG
ATGCCGCTATCACGCTGGCTGATGCCGTTAATTTTCTGGTGGAGAAATACGAACTGGTACGTATCGATCGCAGAGGATTT
TCGTGGCTACAACAGACTCCCTATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGATTGCTAAAAGCTAA
CGTGAAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9238.26 Da        Isoelectric Point: 4.6145

>AT177683 WP_159618118.1 NZ_CP063169:c3955697-3955452 [Haloactinobacterium sp. RN3S43]
MKTAISLPDEEFERFERVAKRHAMNRSEFFRRAGERLADELEGTSELTRLADAAIEAAGQPAEDRLFLNAAREAASREVE
W

Download         Length: 246 bp

>AT177683 NZ_CP083630:c241139-240822 [Leclercia adecarboxylata]
ATGAGCAACATCACATGGGGCCTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCGGCT
GCATTATCTGGCTGACCGGGCCAGTATCACAGGTAAATTCAGTGACGCCGAATGCCAGAAGCTGGATGTGGCATTTCCAC
ACTTTATCAGCCAGATGGAGTCCATGCTGATTACCGGTGAACTTAATCCCCGACACGCCCACTGCGTCATTCTGTACCAT
AACGATTTTACCTGCGAAGCCGACACTCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References