Detailed information of TA system TA177682

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2921722..2922260
• Replicon: chromosome
• Accession: NZ_CP063169
• Organism: Haloactinobacterium sp. RN3S43

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IM660_RS13045
• Protein ID: WP_193496091.1
• Coordinates: 2921722..2921988 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IM660_RS13050
• Protein ID: WP_193496093.1
• Coordinates: 2921985..2922260 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IM660_RS13020	2916935..2919025	+	2091	WP_193496085.1	alpha-galactosidase	-
IM660_RS13025	2919004..2919165	-	162	WP_210768980.1	hypothetical protein	-
IM660_RS13030	2919394..2919630	-	237	WP_210769149.1	hypothetical protein	-
IM660_RS13035	2919735..2920043	-	309	WP_193496087.1	hypothetical protein	-
IM660_RS13040	2920878..2921420	-	543	WP_193496089.1	hypothetical protein	-
IM660_RS13045	2921722..2921988	-	267	WP_193496091.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IM660_RS13050	2921985..2922260	-	276	WP_193496093.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IM660_RS13055	2922328..2923176	-	849	WP_193496095.1	biotin-dependent carboxyltransferase family protein	-
IM660_RS13060	2923176..2923778	-	603	WP_193496097.1	5-oxoprolinase subunit PxpB	-
IM660_RS13065	2923775..2924518	-	744	WP_193496099.1	LamB/YcsF family protein	-
IM660_RS13070	2924515..2925432	-	918	WP_193496101.1	hypothetical protein	-
IM660_RS13075	2925461..2926267	-	807	WP_193496102.1	ECF transporter S component	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 9854.33 Da
• Isoelectric Point: 8.5549

>T177682 WP_193496091.1 NZ_CP063169:c2921988-2921722 [Haloactinobacterium sp. RN3S43]
MTWEVQFAPSAVRGLDRLPPRIVGAVVEFITVTLPTNPERMSKPLAGELEGYRSARRGDYRVIFSLDDATSELLVIRVAH
RADVYRPG

Nucleotide

• Length: 267 bp

>T177682 NZ_CP083627:c2069342-2069088 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10304.47 Da
• Isoelectric Point: 4.7132

>AT177682 WP_193496093.1 NZ_CP063169:c2922260-2921985 [Haloactinobacterium sp. RN3S43]
MKTVTLSDAKDKLSGYLDEVETEHEIVRITRHGRGSAVLISQDDLDSLRETIFWLSQPGIREDIAEARRSVEESSTMSAD
DVRTRYGLPPR

Nucleotide

• Length: 276 bp

>AT177682 NZ_CP083627:c2069586-2069344 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA