Detailed information of TA system TA177681

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1190719..1191353
• Replicon: chromosome
• Accession: NZ_CP063169
• Organism: Haloactinobacterium sp. RN3S43

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IM660_RS05025
• Protein ID: WP_193499223.1
• Coordinates: 1190967..1191353 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IM660_RS05020
• Protein ID: WP_193498307.1
• Coordinates: 1190719..1190967 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IM660_RS04995	1186292..1187062	+	771	WP_193498302.1	SDR family oxidoreductase	-
IM660_RS05000	1187062..1188036	+	975	WP_193498303.1	dihydropteroate synthase	-
IM660_RS05005	1188033..1188740	+	708	WP_193498304.1	pyrimidine reductase family protein	-
IM660_RS05010	1188863..1189855	-	993	WP_193498305.1	hypothetical protein	-
IM660_RS05015	1189852..1190505	-	654	WP_193498306.1	Pr6Pr family membrane protein	-
IM660_RS05020	1190719..1190967	+	249	WP_193498307.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
IM660_RS05025	1190967..1191353	+	387	WP_193499223.1	type II toxin-antitoxin system VapC family toxin	Toxin
IM660_RS05030	1191485..1193290	+	1806	WP_193498308.1	methionine--tRNA ligase	-
IM660_RS05035	1193280..1194188	+	909	WP_193498309.1	TatD family hydrolase	-
IM660_RS05040	1194331..1195407	+	1077	WP_193498310.1	G5 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

• Antitoxin VapB-like (1-81)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 13896.73 Da
• Isoelectric Point: 4.8781

>T177681 WP_193499223.1 NZ_CP063169:1190967-1191353 [Haloactinobacterium sp. RN3S43]
IAVDTSALVTIVLGEPELERFAAIMASRPCVVSTSSITEAALVVQTRQGPDAVEDLRRVLQQAKVEIAPVDEEQAWSAHA
AWQRFGKGRHPAGLNYGDCFSYALAKTRAVPLLYQGEGFTQTDIEPAR

Nucleotide

• Length: 387 bp

>T177681 NZ_CP083627:1881754-1882512 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGTCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATACACCAAAGATTTTGCAGGGAAAATGGTAGAGTCTTTAGTAACCGAATTGAGTCA
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACTATTGATGTTCCAAAGAAAACAGCACAACTATTAAAAAATA
AGGGGTATGAGGTACAATTAGCCTTAATTGCAACCAAGCCCGAATTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTATGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTGGCTATCTTTGAAAGCATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAACCGTTCTTCATGATTTACTATTTGGAGAATTGAATCAAGTGGAGAAAGAGATGCTT
AAATCAGGAGAAGAAAGATTGAAAGATTTAACTAATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8930.22 Da
• Isoelectric Point: 5.8041

>AT177681 WP_193498307.1 NZ_CP063169:1190719-1190967 [Haloactinobacterium sp. RN3S43]
MALNIKDPETDRLARELADRMGVSITAALKAALTDRLARTTPKVDVVYTSLVAVGERGRARAVLDDRPVDQIITYDDHGL
PA

Nucleotide

• Length: 249 bp

>AT177681 NZ_CP083627:1881278-1881754 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCAAGGATTGTAGGTATTTC
ACGAAATAGTCTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATCGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGTATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCAGACAAATATCTATTTAGTAGAAAATTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA