Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1086624..1087150 Replicon chromosome
Accession NZ_CP063169
Organism Haloactinobacterium sp. RN3S43

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IM660_RS04590 Protein ID WP_193498231.1
Coordinates 1086624..1086947 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag IM660_RS04595 Protein ID WP_159621332.1
Coordinates 1086944..1087150 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM660_RS04575 1083391..1084083 + 693 WP_193498228.1 DNA alkylation repair protein -
IM660_RS04580 1084097..1085197 - 1101 WP_193498229.1 putative sulfate exporter family transporter -
IM660_RS04585 1085269..1086159 + 891 WP_193498230.1 LysR family transcriptional regulator -
IM660_RS04590 1086624..1086947 - 324 WP_193498231.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IM660_RS04595 1086944..1087150 - 207 WP_159621332.1 DUF3018 family protein Antitoxin
IM660_RS19740 1087368..1087973 + 606 WP_210769075.1 helix-turn-helix domain-containing protein -
IM660_RS04605 1087970..1089250 + 1281 WP_193498232.1 MFS transporter -
IM660_RS04610 1089228..1089626 + 399 WP_193498233.1 hypothetical protein -
IM660_RS04615 1089709..1090599 - 891 WP_193498234.1 formate dehydrogenase accessory sulfurtransferase FdhD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-102)

Antitoxin

Antitoxin MazE-like

(4-67)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11619.48 Da        Isoelectric Point: 11.5572

>T177680 WP_193498231.1 NZ_CP063169:c1086947-1086624 [Haloactinobacterium sp. RN3S43]
VNRGEIWTVAGGVYASKPRPALIVQDDAFAQTGSVTVLPLTTSLTDAPLLRLRLRSGEAGLTRHSDIMIDKLTTVRRSSV
GTRVGRVSTERLVEIERALMAFLGMAR

Download         Length: 324 bp

>T177680 NZ_CP063169:c1086947-1086624 [Haloactinobacterium sp. RN3S43]
GTGAACCGCGGCGAGATCTGGACCGTGGCGGGCGGCGTGTATGCGAGCAAGCCGAGGCCGGCCCTCATTGTTCAGGACGA
CGCGTTCGCCCAGACCGGCTCGGTGACGGTGTTGCCATTAACGACGTCCCTGACCGATGCACCATTGCTGCGGCTCCGGT
TGCGATCCGGCGAGGCGGGCCTCACCCGGCACAGCGACATCATGATCGACAAACTCACCACGGTGCGGCGATCCAGCGTC
GGCACACGCGTGGGCCGCGTGAGCACCGAGCGCCTGGTCGAGATCGAACGAGCGCTGATGGCGTTCCTCGGGATGGCTCG
CTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 8037.86 Da        Isoelectric Point: 4.4805

>AT177680 WP_159621332.1 NZ_CP063169:c1087150-1086944 [Haloactinobacterium sp. RN3S43]
MAVRERVSEYRRRMRERGYRPVQIWVPDVRSEVFAAEAARQSALVAQADAHTDDQEFIEQVSVDWDEE

Download         Length: 207 bp

>AT177680 NZ_CP063169:c1087150-1086944 [Haloactinobacterium sp. RN3S43]
ATGGCAGTCAGGGAGCGCGTGTCCGAGTACCGGCGCCGCATGCGGGAGCGCGGCTACCGGCCGGTGCAGATCTGGGTGCC
AGACGTCCGCAGCGAGGTGTTCGCAGCCGAGGCAGCACGCCAGTCGGCCCTCGTCGCCCAGGCAGATGCTCACACCGACG
ATCAGGAGTTCATCGAACAGGTCTCGGTCGACTGGGACGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References