Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1888275..1888949 Replicon plasmid unnamed
Accession NZ_CP063167
Organism Variovorax paradoxus strain VAI-C

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag INQ48_RS39935 Protein ID WP_203206934.1
Coordinates 1888530..1888949 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag INQ48_RS39930 Protein ID WP_203206933.1
Coordinates 1888275..1888529 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INQ48_RS39905 1883279..1883746 - 468 WP_093347148.1 hypothetical protein -
INQ48_RS39910 1883739..1884146 - 408 WP_203206929.1 hypothetical protein -
INQ48_RS39915 1884418..1884921 + 504 WP_203206930.1 hypothetical protein -
INQ48_RS39920 1884972..1887206 + 2235 WP_203206931.1 hypothetical protein -
INQ48_RS39925 1887339..1888142 + 804 WP_203206932.1 alpha/beta hydrolase -
INQ48_RS39930 1888275..1888529 + 255 WP_203206933.1 plasmid stabilization protein Antitoxin
INQ48_RS39935 1888530..1888949 + 420 WP_203206934.1 type II toxin-antitoxin system VapC family toxin Toxin
INQ48_RS39940 1888965..1890287 - 1323 WP_203206935.1 hypothetical protein -
INQ48_RS39945 1890430..1890786 - 357 WP_203206936.1 hypothetical protein -
INQ48_RS39950 1890801..1891772 - 972 WP_093347169.1 hypothetical protein -
INQ48_RS39955 1891912..1892628 - 717 WP_203206937.1 GntR family transcriptional regulator -
INQ48_RS39960 1892721..1893698 + 978 WP_064262198.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA / adeG / kdsA 1..2479635 2479635


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15046.16 Da        Isoelectric Point: 4.9057

>T177679 WP_203206934.1 NZ_CP063167:1888530-1888949 [Variovorax paradoxus]
MIVLDTNVVSEAMKPEPDAAVRAWLNDQAAESLYLSSVTLAELLFGIRALPAGKRKNLLDRALRELLELFKDRVLPFDTD
AARHYADLAVTARSGGRGFPTPDGYIAAIAASRGFIVASRDTSPYEAAGLTVINPWTEA

Download         Length: 420 bp

>T177679 NZ_CP083627:c426816-426562 [Streptococcus pneumoniae]
ATGCTACTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9246.65 Da        Isoelectric Point: 10.1758

>AT177679 WP_203206933.1 NZ_CP063167:1888275-1888529 [Variovorax paradoxus]
MAILTVRNVPDDVHRALRVRAAQHGRSTEAEVREILASVVKPEKRVLVGDALAAIGRKIGLTNEDFAVFENVRDKTPAKP
LSFD

Download         Length: 255 bp

>AT177679 NZ_CP083627:c427074-426820 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References