177678

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParE-CopA/ParE-RHH
Location 1288403..1288989 Replicon plasmid unnamed
Accession NZ_CP063167
Organism Variovorax paradoxus strain VAI-C

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag INQ48_RS37085 Protein ID WP_203206434.1
Coordinates 1288693..1288989 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name copA Uniprot ID -
Locus tag INQ48_RS37080 Protein ID WP_057596819.1
Coordinates 1288403..1288705 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INQ48_RS37065 1283792..1286347 - 2556 WP_203206432.1 TonB-dependent siderophore receptor -
INQ48_RS37070 1286434..1287450 - 1017 WP_203206433.1 FecR domain-containing protein -
INQ48_RS37075 1287447..1287956 - 510 WP_057596820.1 sigma-70 family RNA polymerase sigma factor -
INQ48_RS37080 1288403..1288705 + 303 WP_057596819.1 CopG family ribbon-helix-helix protein Antitoxin
INQ48_RS37085 1288693..1288989 + 297 WP_203206434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INQ48_RS37090 1289400..1290854 - 1455 WP_203206435.1 amidase -
INQ48_RS37095 1290984..1291892 + 909 WP_203208475.1 LysR family transcriptional regulator -
INQ48_RS37100 1292518..1292925 - 408 WP_203206436.1 helix-turn-helix domain-containing protein -
INQ48_RS37105 1293445..1293906 - 462 WP_203206437.1 winged helix DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA / adeG / kdsA 1..2479635 2479635


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-50)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11246.98 Da        Isoelectric Point: 9.4507

>T177678 WP_203206434.1 NZ_CP063167:1288693-1288989 [Variovorax paradoxus]
MPQVRFTPAALRDLQRLREFLRPKNPQAARRAALSILQGVKVLGLQPLIGRPLEDLPPEYREWVIDFGSGGYVSLYRYDE
DIDVVTVLALRHQREAGY

Download         Length: 297 bp

>T177678 NZ_CP083621:c203801-202476 [Enterobacter bugandensis]
ATGAGCCGGAAACAGCAGCGTCTGGCAATCTGGATGAACGGAATCAAAGTCGGATACTGGGAAAAAAGTAAAGGGGTAGA
CAGCTTACAATACCTTCCTGACTGGAGTGCAGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTCCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTTCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACAGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGCGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGAACAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAAACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCATTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAAGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAGTTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCACTCTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11414.73 Da        Isoelectric Point: 5.9822

>AT177678 WP_057596819.1 NZ_CP063167:1288403-1288705 [Variovorax paradoxus]
MTTASSSSSIAPTPVKLDPQLKGRLKRLAEARHRAPHWLMREAIAQYVEREEKRQELHEQAVAAWDEFQQTGLHVTAEEV
SAWLASWGTDNEQPEPECHK

Download         Length: 303 bp

>AT177678 NZ_CP083621:c204099-203806 [Enterobacter bugandensis]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGTTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGGGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCTATCCTGGGCGTAAAAATCAGCTTCTCCTCGACAACCGCCTCTTCAGAGGGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References