Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 1145362..1145942 Replicon plasmid unnamed
Accession NZ_CP063167
Organism Variovorax paradoxus strain VAI-C

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag INQ48_RS36415 Protein ID WP_203208293.1
Coordinates 1145562..1145942 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag INQ48_RS36410 Protein ID WP_203208463.1
Coordinates 1145362..1145565 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INQ48_RS36385 1140545..1141219 - 675 WP_203208288.1 response regulator -
INQ48_RS36390 1141285..1141989 - 705 WP_203208289.1 VIT family protein -
INQ48_RS36395 1141986..1142234 - 249 WP_203208290.1 hypothetical protein -
INQ48_RS36400 1143169..1143603 - 435 WP_203208291.1 helix-turn-helix domain-containing protein -
INQ48_RS36405 1143530..1144897 - 1368 WP_203208292.1 HipA domain-containing protein -
INQ48_RS36410 1145362..1145565 + 204 WP_203208463.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
INQ48_RS36415 1145562..1145942 + 381 WP_203208293.1 VapC toxin family PIN domain ribonuclease Toxin
INQ48_RS36420 1146015..1146350 + 336 WP_203208294.1 hypothetical protein -
INQ48_RS36425 1146802..1147689 - 888 WP_203208295.1 LysR family transcriptional regulator -
INQ48_RS36430 1147891..1148952 + 1062 WP_203208464.1 aldo/keto reductase -
INQ48_RS36435 1149388..1150851 + 1464 WP_203208296.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA / adeG / kdsA 1..2479635 2479635


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14101.45 Da        Isoelectric Point: 6.7486

>T177677 WP_203208293.1 NZ_CP063167:1145562-1145942 [Variovorax paradoxus]
MTLVLVDTSVWVDHFRARNSTLEQLLGLDQVLIHPMVIGELACGTPPARTQTLGYLHHLQHVQQASLREVLLFIEKERLF
GLGCGLVDLTLVASTLMTPGAELWSLDKRLNDMTQRFAVGYRPAVH

Download         Length: 381 bp

>T177677 NZ_CP083620:c4215933-4215649 [Enterobacter bugandensis]
ATGATTTATGAACTGGAGTTCGACCCGAGGGCTTTAAAGGAGTGGCATAAGCTGGGCGATACGGTGAAATGCCAGTTTAA
AAAGAAACTTGCTGACGTCTTAGTGAACCCCAGAATTGAATCGGCCCGCCTGCACGGCCTGTCGGATTGCTACAAAATAA
AACTCAGATCTCTGGGTTATCGTTTGGTTTATCAGGTTCAGGATAACGTAGTTACGGTATTTGTTATCGCTATCGGAAAG
AGAGAGAAATCAGCCGTTTATCATGAAGCAAATAAACGGCTTTAG

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7480.62 Da        Isoelectric Point: 8.6599

>AT177677 WP_203208463.1 NZ_CP063167:1145362-1145565 [Variovorax paradoxus]
MRTTVTIDDALYEEALKVADPSMDKADLFREAIKTFVRVQSAKRLAALGGRMPEMPDIPRRREGTGS

Download         Length: 204 bp

>AT177677 NZ_CP083620:c4216165-4215923 [Enterobacter bugandensis]
ATGGCCACGCTTAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCGTATGCCGTGCTGGAAAAACTCAATATTACCCC
AACGGAAGCCGTGCGGTTACTGTTTCAGTACGTTGCGGAAACAGGGCGTATGCCGGTGAAAACTGTCACCATCAGTGACA
GTGAAGATGAACTGATACAGACAGTCCGGGAGCGACTGGCGAATCCACAAAAGGGAATTAAGGTTAGTCTGGATGATTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References