Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4040241..4041975 Replicon chromosome
Accession NZ_CP063166
Organism Variovorax paradoxus strain VAI-C

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag INQ48_RS19015 Protein ID WP_203206234.1
Coordinates 4041118..4041975 (-) Length 286 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag INQ48_RS19010 Protein ID WP_203201511.1
Coordinates 4040241..4041077 (-) Length 279 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INQ48_RS18990 4035383..4036858 - 1476 WP_203201508.1 aldehyde dehydrogenase -
INQ48_RS18995 4036867..4037664 - 798 WP_093344534.1 aspartate dehydrogenase -
INQ48_RS19000 4037697..4039403 - 1707 WP_203201509.1 thiamine pyrophosphate-binding protein -
INQ48_RS19005 4039396..4040235 - 840 WP_203201510.1 SDR family oxidoreductase -
INQ48_RS19010 4040241..4041077 - 837 WP_203201511.1 IclR family transcriptional regulator Antitoxin
INQ48_RS19015 4041118..4041975 - 858 WP_203206234.1 alpha/beta fold hydrolase Toxin
INQ48_RS19020 4041987..4042535 - 549 WP_203201512.1 cupin domain-containing protein -
INQ48_RS19025 4042569..4043384 - 816 WP_203201513.1 SDR family oxidoreductase -
INQ48_RS19030 4043392..4044375 - 984 WP_203201514.1 tripartite tricarboxylate transporter substrate binding protein -
INQ48_RS19035 4044564..4045820 - 1257 WP_203201515.1 D-amino acid dehydrogenase -
INQ48_RS19040 4045873..4046889 - 1017 WP_203201516.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(47-277)

Antitoxin

Transcription regulator IclR, C-terminal

(140-259)


Sequences

Toxin        


Download         Length: 286 a.a.        Molecular weight: 29772.16 Da        Isoelectric Point: 6.2583

>T177675 WP_203206234.1 NZ_CP063166:c4041975-4041118 [Variovorax paradoxus]
MQTTDIQASMPPASELARLDARFAAREVAVAGGAVVSVRERGQGPAIVCLHGIGSGAASWLEVAELLAPEARLIAWDAPG
YGASTPLEADAPTAADYAARLSALLDALAIDSCLLLGHSLGAIVAAAAARRDARIRRLLLVSPAIGYGAAQRAEARAKVR
AERLATLDQLGIAGMAAQRAGRLLSDNASEPARQWVRWNMARLNDRGYRQAVELLCNADLLAELPPPMPVRVACGALDAV
TPPAACEDVARRCGVALELVDDAGHAGYVEQPRAVAALLRESLAR

Download         Length: 858 bp

>T177675 NZ_CP083620:3118149-3118622 [Enterobacter bugandensis]
ATGATTTTTTATCGGCTGGTGACGGGACGCTATGCCAGCGAAGCGTGGAGTGGAAGCGGCGCAAATCAGTACGGTGGTCG
CTGGAATCATAAAGGGCATCCCGCCGTATATGTGTCCACGTCCATCTCGCTGGCCTCACTGGAGATTTTGGTGCACATCA
GAAAAGATACCGTGTTGAATCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATTGATTACCTGGATAAAGCC
TGGCTCCCCGAGGACTGGCAGGAAAATCCGGCACCGGTATCGACGATGGATCTGGGAACCGGGTGGTTGCAGGCTAGCAG
TGCCCTCGCGCTTATCCTACCTTCCTGCATCATACCCTATGAAAACAACGCCATCCTTAACCCCTTACATCCGGCATTCC
ATACGGCGCTCAGTTCTGTTCAGCAGATGCCCTTTATTTTTGATACCCGTCTCGCAGAAAAAACCGCACCCTGA

Antitoxin


Download         Length: 279 a.a.        Molecular weight: 30641.99 Da        Isoelectric Point: 5.7705

>AT177675 WP_203201511.1 NZ_CP063166:c4041077-4040241 [Variovorax paradoxus]
MATNDNDAMEEGADRYNVPALERGLRVLCEFSRESRTLSAPELARRFDLPRSTVFRLLTTLENMGFLERAEGGRDYRLGL
AVLRLGFEYLASLELTQLGTPLLNRLCEELRTPCNLVVRDGRSIVYVAKVAPPTPFASSVTVGTRLPAHATVLGRILLED
LTLPQLRALYPEDKLETFSPSTPKTVNELFDMVQADRQRGYVLGEGFFESNISTIAAPVRDHGGHIVAALGATITSGHID
ENRMDEMVQRVRGTADEISGLLNYSPARAAKVVPLRSA

Download         Length: 837 bp

>AT177675 NZ_CP083620:3117709-3118152 [Enterobacter bugandensis]
ATGAGAACCTGGATCCCCGCCAAGAAACCTGCTGATAACGCACTTTGGCGCTATGCCGGTTTACCCGCGAACAGAGGTAT
GCGGCTGATAGAATTTCTCAACCAGGGATTGCCCGTCAGCGTGCTCGACAATATTCATGAATGGACGGCCATGTCGAAAG
CGGACATTTTGCGCGTTACCGGGATTAACGAACGTAACGTGGCCCGCCGCAAAAGCGCGGGACGGACGCTGACGCCGGAT
GAGAGCGAACGCGTAGCCCGTTTTGTTCGGGTGCTGGATGCGGCCGTCGACTATTTTGGCAGTAAAGAAGAAGCATGGAA
CTGGCTTCAGTCGCCGGTGCGCGGGCTTGGCAATGTTGCGCCTGTTGACCTGATCGCTACGGAAACCGGTGCACTGGAAG
TCACCGATTTGATTGGTCGTCTGGAACACGGAGTGTTTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References