Detailed information of TA system TA177674

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapB-relB/VapC-Phd
• Location: 3389975..3390659
• Replicon: chromosome
• Accession: NZ_CP063166
• Organism: Variovorax paradoxus strain VAI-C

Toxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: INQ48_RS15960
• Protein ID: WP_093341982.1
• Coordinates: 3389975..3390388 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: INQ48_RS15965
• Protein ID: WP_203201016.1
• Coordinates: 3390402..3390659 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INQ48_RS15930	3385122..3386255	+	1134	WP_203201011.1	pentapeptide repeat-containing protein	-
INQ48_RS15935	3386252..3386941	+	690	WP_203201012.1	DUF3540 domain-containing protein	-
INQ48_RS15940	3387051..3387437	+	387	WP_057590264.1	DUF4150 domain-containing protein	-
INQ48_RS15945	3387450..3387764	-	315	WP_203201013.1	hypothetical protein	-
INQ48_RS15950	3387809..3388801	-	993	WP_203201014.1	tripartite tricarboxylate transporter substrate binding protein	-
INQ48_RS15955	3388905..3389978	-	1074	WP_203201015.1	phospholipase	-
INQ48_RS15960	3389975..3390388	-	414	WP_093341982.1	type II toxin-antitoxin system VapC family toxin	Toxin
INQ48_RS15965	3390402..3390659	-	258	WP_203201016.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
INQ48_RS15970	3390724..3393093	-	2370	WP_203201017.1	RNA-binding transcriptional accessory protein	-
INQ48_RS15975	3393237..3393767	+	531	WP_203201018.1	hypothetical protein	-
INQ48_RS15980	3393833..3394210	+	378	WP_203201019.1	GIY-YIG nuclease family protein	-
INQ48_RS15985	3394314..3394883	+	570	WP_203201020.1	DUF2239 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-117)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-63)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15112.21 Da
• Isoelectric Point: 5.1407

>T177674 WP_093341982.1 NZ_CP063166:c3390388-3389975 [Variovorax paradoxus]
MYLLDTNVISELRKPRPHGAVIAWLTPIADSELHLSAVTLGEIQAGIELTREQDAAKADEIEQWAALVAGSYNVLPMDAD
TFRLWAKLMHRSSNTLYEDAMIAATARQHSLTVVTRNVADFANFGVALLNPFEHGKP

Nucleotide

• Length: 414 bp

>T177674 NZ_CP083620:c2985547-2985047 [Enterobacter bugandensis]
ATGTTTTCAGAGGGAACCGACTATGATTTCGGGGATTTTGATTGTGGTGAACCCTCGCTAAATGCCTTCCTGAGAGAACA
CCTGGTACGCCAGCACAATGGACGTATTCTACGAGCCTACCTGCTTAAAGAGCGCGACCATCCGCGCGTGCTGGGCTATT
ACACGCTATCGGGAAGTTGCTTTGAGAGAGCGATGCTTCCTTCTAAGACCCAGCAGCGTCGGATCCCTTATCTCAACGTA
CCCAGCGTGACGCTGGGACGTCTGGCTATTCATAAAGAACTACAGGGAAACGAGTGGGGAACAACGCTTGTTGCACACGC
TATGCGGGTGGTTTACCTGGCGTCGCAGGCTGTGGGAGTACATGGAATATTTGTTGATGCCCTTAGCGAGCAGGCTAAAC
GATTTTATCTGAAGCTGGGGTTCATCCCGCTGGCAGGCGAAAACAGCCATTCTTTGTTCTTCCCGACAAAAGCTATCGAA
CGACTGTTTGAGCAGGCGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9536.16 Da
• Isoelectric Point: 11.1716

>AT177674 WP_203201016.1 NZ_CP063166:c3390659-3390402 [Variovorax paradoxus]
MKSWPVQDAKARFSEFLEACLAEGPQMVTKRGAEAAVLVPAAEWRRLHATARPSLKELLLAPEARTEFLVPERGAARRRK
VTPLR

Nucleotide

• Length: 258 bp

>AT177674 NZ_CP083620:c2985844-2985575 [Enterobacter bugandensis]
ATGCCAGCACTTAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCGGCGAT
GACGAATCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCAGAGGTCATCGAGCAGCACCGTCGTC
TCGTGTTAAACGAAGCCTCCTGGAATGCGGTGATGGATGCTATCGACAATCCGCCAGAGCCAAATGAACGCCTCAAGCGA
GCGGCAAAACGTCTTCGAAACATGGAGTGA