Detailed information of TA system TA177673

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1518925..1519453
• Replicon: chromosome
• Accession: NZ_CP063164
• Organism: Sulfurovum indicum strain ST-419

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IMZ28_RS07555
• Protein ID: WP_197547976.1
• Coordinates: 1518925..1519212 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IMZ28_RS07560
• Protein ID: WP_197547977.1
• Coordinates: 1519202..1519453 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMZ28_RS07540	1515083..1515646	+	564	WP_197547973.1	hypothetical protein	-
IMZ28_RS07545	1515761..1516984	-	1224	WP_197547974.1	serine protease	-
IMZ28_RS07550	1517047..1518924	-	1878	WP_197547975.1	TRAP transporter large permease subunit	-
IMZ28_RS07555	1518925..1519212	-	288	WP_197547976.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IMZ28_RS07560	1519202..1519453	-	252	WP_197547977.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
IMZ28_RS07565	1519519..1520319	-	801	WP_197547978.1	hypothetical protein	-
IMZ28_RS07570	1520394..1520816	+	423	WP_197547979.1	META domain-containing protein	-
IMZ28_RS07575	1520890..1522344	-	1455	WP_197547980.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
IMZ28_RS07580	1522344..1523072	-	729	WP_197547981.1	alpha/beta hydrolase	-
IMZ28_RS07585	1523123..1524061	-	939	WP_197547982.1	murein L,D-transpeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-75)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11410.37 Da
• Isoelectric Point: 10.3854

>T177673 WP_197547976.1 NZ_CP063164:c1519212-1518925 [Sulfurovum indicum]
MSYELHFKPKALKEWKKLNHSVKEQFKKKLKERLEQPKVVKDRLKGYENIYKIKLRSVGYRLAYEVKDEEVIVLVLVSGK
RENNSIYDNLKARSE

Nucleotide

• Length: 288 bp

>T177673 NZ_CP083620:1846203-1846306 [Enterobacter bugandensis]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9391.61 Da
• Isoelectric Point: 4.1064

>AT177673 WP_197547977.1 NZ_CP063164:c1519453-1519202 [Sulfurovum indicum]
MTQILANYTASISELKKSPSSVIEEANGETVAILNHNKPSAYLVPSDVYENMMDILDDYYLMKEVEERLNDGQKPIKVNI
DEL

Nucleotide

• Length: 252 bp

>AT177673 NZ_CP083620:c1846310-1846168 [Enterobacter bugandensis]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT