Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4486720..4487332 Replicon chromosome
Accession NZ_CP063153
Organism Escherichia coli strain M7424

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag INR48_RS21455 Protein ID WP_000833473.1
Coordinates 4487147..4487332 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5F1W1Z0
Locus tag INR48_RS21450 Protein ID WP_000499743.1
Coordinates 4486720..4487130 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INR48_RS21435 4482232..4483047 - 816 WP_000891838.1 AraC family transcriptional regulator -
INR48_RS21440 4483273..4484673 + 1401 WP_000204798.1 MFS transporter -
INR48_RS21445 4484684..4486648 + 1965 WP_001026870.1 glycoside hydrolase family 127 protein -
INR48_RS21450 4486720..4487130 - 411 WP_000499743.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
INR48_RS21455 4487147..4487332 - 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
INR48_RS21460 4487601..4489139 - 1539 WP_001306609.1 aldehyde dehydrogenase AldB -
INR48_RS21465 4489340..4490491 - 1152 WP_000741501.1 L-threonine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T177660 WP_000833473.1 NZ_CP063153:c4487332-4487147 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

>T177660 NZ_CP083613:c407498-407106 [Enterobacter hormaechei subsp. oharae]
ATGCTGCATATGCTGGACACTAACATCGTAAGCCATCTGGTGAGGCAGCATCCTGAAGTTGTAAACCGATATTCGCAAAT
TACGCCTGAAAAGATGTGTATTTCAAGCGTAACGGAAGCGGAATTGCTTTACGGCGTAGCCAAAAAGCAAAACAACAAGC
TGCACGAAACCATAATGGAATTTCTTAAAACCATCACTGTCTGCGCCTGGGATAGCGAAGCCGCAGCCATCTACGGTGAA
CTGCGTGCGGCAATGGAAAAGAAAGGGAAAGTGATGGGGGATCTCGATCAGTTGATTGCCGCACATGCTATCAGCCGGGG
CACGACGATTGTCACGAACGATCATGCGTTCGGGATGGTACAGGATCTTACGGTTGAGGACTGGACTCAATAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15213.09 Da        Isoelectric Point: 4.5486

>AT177660 WP_000499743.1 NZ_CP063153:c4487130-4486720 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGA

Download         Length: 411 bp

>AT177660 NZ_CP083613:c407762-407502 [Enterobacter hormaechei subsp. oharae]
ATGGAACGCACAGCGAAACTATTCAAAAAAGGACGAAACCAGGCCGTGGTCTTGCCTGCGGAATTTGCGTTTGAAACGGA
GAGTGTTTATATCCGCCGGGATGACGAGGGGAATGTGGTTTTGACGGCAAGGTCCGAGAAAGCACGGCACAGGGATAACT
TTTTGCGCATGTTAAAAGAAACGCATGTGCCTGATACCTTTCTAAGTAAAGAGGAGCGCAATCAGAGCTATACGACAAGA
AACCCTCTTGAAGGGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A5F1W1Z0

References