177645

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2098410..2099048 Replicon chromosome
Accession NZ_CP063153
Organism Escherichia coli strain M7424

Toxin (Protein)


Gene name hicA Uniprot ID B7N4J4
Locus tag INR48_RS09955 Protein ID WP_000813797.1
Coordinates 2098410..2098586 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag INR48_RS09960 Protein ID WP_076611057.1
Coordinates 2098632..2099048 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INR48_RS09935 2094032..2095243 - 1212 WP_001323162.1 BenE family transporter YdcO -
INR48_RS09940 2095296..2095832 + 537 WP_000429161.1 DNA-binding transcriptional regulator SutR -
INR48_RS09945 2095905..2097866 + 1962 WP_001309488.1 23S rRNA 5-hydroxycytidine C2501 synthase -
INR48_RS09950 2097958..2098188 - 231 WP_000494244.1 YncJ family protein -
INR48_RS09955 2098410..2098586 + 177 WP_000813797.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
INR48_RS09960 2098632..2099048 + 417 WP_076611057.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
INR48_RS09965 2099127..2100533 + 1407 WP_000760613.1 PLP-dependent aminotransferase family protein -
INR48_RS09970 2100778..2101923 + 1146 WP_000047449.1 ABC transporter substrate-binding protein -
INR48_RS09975 2101941..2102954 + 1014 WP_000220413.1 ABC transporter ATP-binding protein -
INR48_RS09980 2102955..2103896 + 942 WP_001251335.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6724.76 Da        Isoelectric Point: 11.5666

>T177645 WP_000813797.1 NZ_CP063153:2098410-2098586 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T177645 NZ_CP083610:3437715-3437818 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15251.65 Da        Isoelectric Point: 4.5908

>AT177645 WP_076611057.1 NZ_CP063153:2098632-2099048 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLTNNDHFIEVPLSIASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT177645 NZ_CP083610:c3437856-3437585 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J715

Antitoxin

Source ID Structure

References