Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 374419..375014 Replicon chromosome
Accession NZ_CP063153
Organism Escherichia coli strain M7424

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag INR48_RS01775 Protein ID WP_000239581.1
Coordinates 374664..375014 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag INR48_RS01770 Protein ID WP_001223213.1
Coordinates 374419..374670 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INR48_RS01760 370084..373863 + 3780 WP_000060960.1 autotransporter assembly complex protein TamB -
INR48_RS01765 373866..374207 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
INR48_RS01770 374419..374670 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
INR48_RS01775 374664..375014 + 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
INR48_RS01780 375093..375623 - 531 WP_000055075.1 inorganic diphosphatase -
INR48_RS01785 375933..376889 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
INR48_RS01790 377029..378531 + 1503 WP_000205837.1 sugar ABC transporter ATP-binding protein -
INR48_RS01795 378545..379567 + 1023 WP_001367697.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T177634 WP_000239581.1 NZ_CP063153:374664-375014 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T177634 NZ_CP083610:1665106-1665213 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT177634 WP_001223213.1 NZ_CP063153:374419-374670 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT177634 NZ_CP083610:c1665057-1664991 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References