Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 1344601..1345517 | Replicon | chromosome |
| Accession | NZ_CP063150 | ||
| Organism | Bacillus subtilis strain s-16 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | IMY14_RS07020 | Protein ID | WP_047182497.1 |
| Coordinates | 1344771..1345517 (-) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | G4EXD8 |
| Locus tag | IMY14_RS07015 | Protein ID | WP_003232646.1 |
| Coordinates | 1344601..1344771 (-) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IMY14_RS06975 (1340319) | 1340319..1340648 | + | 330 | WP_047182492.1 | XkdW family protein | - |
| IMY14_RS06980 (1340645) | 1340645..1340809 | + | 165 | WP_047182493.1 | XkdX family protein | - |
| IMY14_RS06985 (1340853) | 1340853..1341692 | + | 840 | WP_047182494.1 | phage-like element PBSX protein XepA | - |
| IMY14_RS06990 (1341745) | 1341745..1342014 | + | 270 | WP_003232655.1 | hemolysin XhlA family protein | - |
| IMY14_RS06995 (1342026) | 1342026..1342289 | + | 264 | WP_015483133.1 | phage holin | - |
| IMY14_RS07000 (1342302) | 1342302..1343198 | + | 897 | WP_047182495.1 | N-acetylmuramoyl-L-alanine amidase | - |
| IMY14_RS07005 (1343275) | 1343275..1344366 | + | 1092 | WP_047182496.1 | acyltransferase family protein | - |
| IMY14_RS07010 (1344363) | 1344363..1344515 | - | 153 | WP_131228329.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISC | - |
| IMY14_RS07015 (1344601) | 1344601..1344771 | - | 171 | WP_003232646.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISB | Antitoxin |
| IMY14_RS07020 (1344771) | 1344771..1345517 | - | 747 | WP_047182497.1 | toxin-antitoxin-antitoxin system toxin SpoIISA | Toxin |
| IMY14_RS07025 (1345627) | 1345627..1346628 | - | 1002 | WP_003232642.1 | inorganic phosphate transporter | - |
| IMY14_RS07030 (1346641) | 1346641..1347258 | - | 618 | WP_003218470.1 | DUF47 domain-containing protein | - |
| IMY14_RS07035 (1347534) | 1347534..1348850 | - | 1317 | WP_041850924.1 | serine/threonine exchanger | - |
| IMY14_RS07040 (1349239) | 1349239..1350189 | + | 951 | WP_047182498.1 | ring-cleaving dioxygenase | - |
| IMY14_RS07045 (1350290) | 1350290..1350436 | + | 147 | WP_019258173.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1307860..1387371 | 79511 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29043.47 Da Isoelectric Point: 4.6191
>T177620 WP_047182497.1 NZ_CP063150:c1345517-1344771 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKISAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKISAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
Download Length: 747 bp
>T177620 NZ_CP083604:1113737-1113997 [Macrococcus armenti]
ATGTACAAAATTGTAATGAAATCTAGTGTTAAGAAAGATTTAAAGAAGATAAAAAACACGCACTTAGAAACGAATTTTCT
AAAAATCATTAATCAGCTTAAAGAAAATCCATATAATAATAACCATTCTTTCGAAAAACTAATCCCCCCAATAAAGGGGT
TTTATTCGAGAAGGATAAATGTACAACATCGTGTTGTTTATACTGTAAATGACGAAGATAAAATTGTAACAATCTATTCA
GCATATGGACATTATGAGTGA
ATGTACAAAATTGTAATGAAATCTAGTGTTAAGAAAGATTTAAAGAAGATAAAAAACACGCACTTAGAAACGAATTTTCT
AAAAATCATTAATCAGCTTAAAGAAAATCCATATAATAATAACCATTCTTTCGAAAAACTAATCCCCCCAATAAAGGGGT
TTTATTCGAGAAGGATAAATGTACAACATCGTGTTGTTTATACTGTAAATGACGAAGATAAAATTGTAACAATCTATTCA
GCATATGGACATTATGAGTGA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6654.72 Da Isoelectric Point: 11.0203
>AT177620 WP_003232646.1 NZ_CP063150:c1344771-1344601 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
Download Length: 171 bp
>AT177620 NZ_CP083604:1113486-1113737 [Macrococcus armenti]
ATGAATACTTATACACCAACAAGTGCTAGAAAAGATTTTTTCAACATCATCAAATCTGTTAATGAAGATAGTAAAGAAAT
ATATATCGCTCCAACTAAAATTGGAGAAAAAGGTGCTGTTTTAGTCGGTGAAGATGATTGGAATGCTATTCAGGAAACTT
TATTCTTATTAGAAAAAGGTATCGCTTATCAAATTGAACAACGTAAAGACGAAGAAGAAATTGATTTTGACAGTACTTGG
GATAATATATAA
ATGAATACTTATACACCAACAAGTGCTAGAAAAGATTTTTTCAACATCATCAAATCTGTTAATGAAGATAGTAAAGAAAT
ATATATCGCTCCAACTAAAATTGGAGAAAAAGGTGCTGTTTTAGTCGGTGAAGATGATTGGAATGCTATTCAGGAAACTT
TATTCTTATTAGAAAAAGGTATCGCTTATCAAATTGAACAACGTAAAGACGAAGAAGAAATTGATTTTGACAGTACTTGG
GATAATATATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|