177617

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 124682..125204 Replicon plasmid pKP19-3088-375k
Accession NZ_CP063149
Organism Klebsiella pneumoniae strain KP19-3088

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag IMY63_RS27655 Protein ID WP_004181778.1
Coordinates 124682..124966 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag IMY63_RS27660 Protein ID WP_004181777.1
Coordinates 124956..125204 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMY63_RS27630 122149..122427 - 279 WP_044349308.1 hypothetical protein -
IMY63_RS27635 123226..123513 - 288 WP_044349311.1 helix-turn-helix transcriptional regulator -
IMY63_RS27640 123518..123949 - 432 WP_044349313.1 hypothetical protein -
IMY63_RS27645 123993..124175 - 183 WP_044349315.1 type II toxin-antitoxin system HicA family toxin -
IMY63_RS27650 124269..124661 + 393 WP_052626761.1 type II toxin-antitoxin system PrlF family antitoxin -
IMY63_RS27655 124682..124966 - 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMY63_RS27660 124956..125204 - 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IMY63_RS27665 125496..127295 + 1800 WP_064371185.1 ATP-dependent helicase -
IMY63_RS27670 127624..128628 + 1005 WP_064371184.1 hypothetical protein -
IMY63_RS27675 128764..129117 + 354 WP_042927270.1 hypothetical protein -
IMY63_RS27680 129177..130034 + 858 WP_064371183.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / aac(3)-IId / mph(A) / sul1 / blaNDM-1 / qacE / qnrB6 / aadA16 / dfrA27 / ARR-3 katA 1..375474 375474


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T177617 WP_004181778.1 NZ_CP063149:c124966-124682 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T177617 NZ_CP083602:1113709-1113969 [Macrococcus armenti]
ATGTACAAAATTGTAATGAAATCTAGTGTTAAGAAAGATTTAAAGAAGATAAAAAACACGCACTTAGAAACGAATTTTCT
AAAAATCATTAATCAGCTTAAAGAAAATCCATATAATAATAACCATTCTTTCGAAAAACTAATCCCCCCAATAAAGGGGT
TTTATTCGAGAAGGATAAATGTACAACATCGTGTTGTTTATACTGTAAATGACGAAGATAAAATTGTAACAATCTATTCA
GCATATGGACATTATGAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT177617 WP_004181777.1 NZ_CP063149:c125204-124956 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT177617 NZ_CP083602:1113458-1113709 [Macrococcus armenti]
ATGAATACTTATACACCAACAAGTGCTAGAAAAGATTTTTTCAACATCATCAAATCTGTTAATGAAGATAGTAAAGAAAT
ATATATCGCTCCAACTAAAATTGGAGAAAAAGGTGCTGTTTTAGTCGGTGAAGATGATTGGAATGCTATTCAGGAAACTT
TATTCTTATTAGAAAAAGGTATCGCTTATCAAATTGAACAACGTAAAGACGAAGAAGAAATTGATTTTGACAGTACTTGG
GATAATATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References