Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 60845..61370 | Replicon | plasmid pKP19-3088-159k |
Accession | NZ_CP063148 | ||
Organism | Klebsiella pneumoniae strain KP19-3088 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | D4HQE7 |
Locus tag | IMY63_RS26420 | Protein ID | WP_013023785.1 |
Coordinates | 61065..61370 (+) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | W8V2V6 |
Locus tag | IMY63_RS26415 | Protein ID | WP_001568025.1 |
Coordinates | 60845..61063 (+) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IMY63_RS26385 | 56335..57024 | + | 690 | WP_020315560.1 | RES family NAD+ phosphorylase | - |
IMY63_RS26390 | 57056..57745 | - | 690 | WP_004193995.1 | hypothetical protein | - |
IMY63_RS26395 | 58012..58267 | + | 256 | Protein_56 | hypothetical protein | - |
IMY63_RS26400 | 58995..59243 | + | 249 | WP_053389907.1 | hypothetical protein | - |
IMY63_RS26405 | 59297..59911 | - | 615 | WP_053389911.1 | hypothetical protein | - |
IMY63_RS26410 | 60421..60675 | + | 255 | Protein_59 | hypothetical protein | - |
IMY63_RS26415 | 60845..61063 | + | 219 | WP_001568025.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
IMY63_RS26420 | 61065..61370 | + | 306 | WP_013023785.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
IMY63_RS26425 | 61539..61934 | + | 396 | WP_162269742.1 | hypothetical protein | - |
IMY63_RS26430 | 61961..62275 | + | 315 | WP_053389906.1 | hypothetical protein | - |
IMY63_RS26435 | 62286..63302 | + | 1017 | WP_017899884.1 | hypothetical protein | - |
IMY63_RS26440 | 63500..64294 | + | 795 | WP_053389905.1 | site-specific integrase | - |
IMY63_RS26445 | 64726..64905 | - | 180 | WP_006788217.1 | hypothetical protein | - |
IMY63_RS26450 | 65025..65651 | - | 627 | WP_004197649.1 | ParA family plasmid-partitioning AAA ATPase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | blaKPC-2 | - | 1..159093 | 159093 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11615.30 Da Isoelectric Point: 6.4672
>T177616 WP_013023785.1 NZ_CP063148:61065-61370 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T177616 NZ_CP083598:c1929434-1929084 [Macrococcus armenti]
ATGAAACGTGGAGATGTTTATTTAGCTGATTTGTCACCGGTAAAGGGATCAGAACAAGGCGGTAAACGCCCTGTTGTCAT
TATTCAGAACAATATAGGTAATAAATATAGCCCAACAGTAATTGTCGCGGCAATTACAGCAAAGATTAACAAAGCAAAGA
TTCCCACCCACGTTGAAATCGGAAAGACGAGTCATCACCTGGAAAAGGATTCGGTAATTCTGTTGGAACAAATAAGAACG
ATAGATAAGAATAGATTGATTGATCATTTAACTGTATTAGATAAAGTGAAGATGAAAGAAGTGGATGTTGCGCTTGCAAT
TAGTCTGGGATTATCAATAGAGAGTGAATAG
ATGAAACGTGGAGATGTTTATTTAGCTGATTTGTCACCGGTAAAGGGATCAGAACAAGGCGGTAAACGCCCTGTTGTCAT
TATTCAGAACAATATAGGTAATAAATATAGCCCAACAGTAATTGTCGCGGCAATTACAGCAAAGATTAACAAAGCAAAGA
TTCCCACCCACGTTGAAATCGGAAAGACGAGTCATCACCTGGAAAAGGATTCGGTAATTCTGTTGGAACAAATAAGAACG
ATAGATAAGAATAGATTGATTGATCATTTAACTGTATTAGATAAAGTGAAGATGAAAGAAGTGGATGTTGCGCTTGCAAT
TAGTCTGGGATTATCAATAGAGAGTGAATAG
Antitoxin
Download Length: 73 a.a. Molecular weight: 8392.34 Da Isoelectric Point: 4.7405
>AT177616 WP_001568025.1 NZ_CP063148:60845-61063 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW
Download Length: 219 bp
>AT177616 NZ_CP083598:c1929575-1929435 [Macrococcus armenti]
ATGAGCCAGAAGCTGGAACAAATGCTTATTGAAGGTTATCAATCTATGGCAGAGATTAATTTATCGATTGCATCAGAGCA
TTACATCTTAGAATGTGAAGTAAACGATAACCATCAGACATTAGCACTAGATGGTGAATAA
ATGAGCCAGAAGCTGGAACAAATGCTTATTGAAGGTTATCAATCTATGGCAGAGATTAATTTATCGATTGCATCAGAGCA
TTACATCTTAGAATGTGAAGTAAACGATAACCATCAGACATTAGCACTAGATGGTGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4ZZW6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4ZZP8 |