Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 4771369..4771885 | Replicon | chromosome |
Accession | NZ_CP063147 | ||
Organism | Klebsiella pneumoniae strain KP19-3088 |
Toxin (Protein)
Gene name | relE | Uniprot ID | J2XDK6 |
Locus tag | IMY63_RS23445 | Protein ID | WP_002886902.1 |
Coordinates | 4771369..4771653 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | R4Y888 |
Locus tag | IMY63_RS23450 | Protein ID | WP_002886901.1 |
Coordinates | 4771643..4771885 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IMY63_RS23420 | 4766853..4767161 | - | 309 | WP_002886907.1 | PTS sugar transporter subunit IIB | - |
IMY63_RS23425 | 4767246..4767419 | + | 174 | WP_002886906.1 | hypothetical protein | - |
IMY63_RS23430 | 4767422..4768165 | + | 744 | WP_002886905.1 | MurR/RpiR family transcriptional regulator | - |
IMY63_RS23435 | 4768522..4770660 | + | 2139 | WP_002886904.1 | anaerobic ribonucleoside-triphosphate reductase | - |
IMY63_RS23440 | 4770901..4771365 | + | 465 | WP_002886903.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
IMY63_RS23445 | 4771369..4771653 | - | 285 | WP_002886902.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
IMY63_RS23450 | 4771643..4771885 | - | 243 | WP_002886901.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
IMY63_RS23455 | 4771963..4773873 | - | 1911 | WP_004152270.1 | BglG family transcription antiterminator | - |
IMY63_RS23460 | 4773896..4775050 | - | 1155 | WP_002886900.1 | lactonase family protein | - |
IMY63_RS23465 | 4775116..4775856 | - | 741 | WP_002886899.1 | KDGP aldolase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11125.95 Da Isoelectric Point: 10.3787
>T177613 WP_002886902.1 NZ_CP063147:c4771653-4771369 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
Download Length: 285 bp
>T177613 NZ_CP083595:c1905293-1904943 [Macrococcus armenti]
ATGAAACGTGGAGATGTTTATTTAGCTGATTTGTCACCGGTAAAGGGATCAGAACAAGGCGGTAAACGCCCCGTTGTCAT
TATTCAGAACAATATAGGTAATAAATATAGCCCAACAGTAATTGTCGCGGCAATTACAGCAAAGATTAACAAAGCAAAGA
ATCCCACCCACGTTGAAATTGGAAAGACGAGTCATCACCTGGAAAAGGATTCGGTAATTCTGTTGGAACAAATAAGAACG
ATAGATAAGAATAGATTGATTGATCATTTAACTGTATTAGATAAAGTGAAGATGAAAGAAGTGGATGTTGCGCTTGCAAT
TAGTCTAGGATTATCAATTGAGAGTGAATAG
ATGAAACGTGGAGATGTTTATTTAGCTGATTTGTCACCGGTAAAGGGATCAGAACAAGGCGGTAAACGCCCCGTTGTCAT
TATTCAGAACAATATAGGTAATAAATATAGCCCAACAGTAATTGTCGCGGCAATTACAGCAAAGATTAACAAAGCAAAGA
ATCCCACCCACGTTGAAATTGGAAAGACGAGTCATCACCTGGAAAAGGATTCGGTAATTCTGTTGGAACAAATAAGAACG
ATAGATAAGAATAGATTGATTGATCATTTAACTGTATTAGATAAAGTGAAGATGAAAGAAGTGGATGTTGCGCTTGCAAT
TAGTCTAGGATTATCAATTGAGAGTGAATAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 9045.55 Da Isoelectric Point: 6.3340
>AT177613 WP_002886901.1 NZ_CP063147:c4771885-4771643 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
Download Length: 243 bp
>AT177613 NZ_CP083595:c1905434-1905294 [Macrococcus armenti]
ATGAGCCAGAAGCTGGAACAAATGCTTATTGAAGGTTATCAATCTATGGCAGAGATTAATTTATCGATTGCATCAGAACA
TTACATTTTAGAATGTGAAGTAAACGATAACCATCAAACATTAGCACTAGATGGTGAATAA
ATGAGCCAGAAGCTGGAACAAATGCTTATTGAAGGTTATCAATCTATGGCAGAGATTAATTTATCGATTGCATCAGAACA
TTACATTTTAGAATGTGAAGTAAACGATAACCATCAAACATTAGCACTAGATGGTGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GMH2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GLP0 |