Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4771369..4771885 Replicon chromosome
Accession NZ_CP063147
Organism Klebsiella pneumoniae strain KP19-3088

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag IMY63_RS23445 Protein ID WP_002886902.1
Coordinates 4771369..4771653 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IMY63_RS23450 Protein ID WP_002886901.1
Coordinates 4771643..4771885 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMY63_RS23420 4766853..4767161 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
IMY63_RS23425 4767246..4767419 + 174 WP_002886906.1 hypothetical protein -
IMY63_RS23430 4767422..4768165 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IMY63_RS23435 4768522..4770660 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
IMY63_RS23440 4770901..4771365 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IMY63_RS23445 4771369..4771653 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMY63_RS23450 4771643..4771885 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IMY63_RS23455 4771963..4773873 - 1911 WP_004152270.1 BglG family transcription antiterminator -
IMY63_RS23460 4773896..4775050 - 1155 WP_002886900.1 lactonase family protein -
IMY63_RS23465 4775116..4775856 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T177613 WP_002886902.1 NZ_CP063147:c4771653-4771369 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T177613 NZ_CP083595:c1905293-1904943 [Macrococcus armenti]
ATGAAACGTGGAGATGTTTATTTAGCTGATTTGTCACCGGTAAAGGGATCAGAACAAGGCGGTAAACGCCCCGTTGTCAT
TATTCAGAACAATATAGGTAATAAATATAGCCCAACAGTAATTGTCGCGGCAATTACAGCAAAGATTAACAAAGCAAAGA
ATCCCACCCACGTTGAAATTGGAAAGACGAGTCATCACCTGGAAAAGGATTCGGTAATTCTGTTGGAACAAATAAGAACG
ATAGATAAGAATAGATTGATTGATCATTTAACTGTATTAGATAAAGTGAAGATGAAAGAAGTGGATGTTGCGCTTGCAAT
TAGTCTAGGATTATCAATTGAGAGTGAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT177613 WP_002886901.1 NZ_CP063147:c4771885-4771643 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT177613 NZ_CP083595:c1905434-1905294 [Macrococcus armenti]
ATGAGCCAGAAGCTGGAACAAATGCTTATTGAAGGTTATCAATCTATGGCAGAGATTAATTTATCGATTGCATCAGAACA
TTACATTTTAGAATGTGAAGTAAACGATAACCATCAAACATTAGCACTAGATGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References