177612

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4670037..4670847 Replicon chromosome
Accession NZ_CP063147
Organism Klebsiella pneumoniae strain KP19-3088

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag IMY63_RS22970 Protein ID WP_002887280.1
Coordinates 4670037..4670570 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag IMY63_RS22975 Protein ID WP_002887278.1
Coordinates 4670581..4670847 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMY63_RS22965 4668868..4669989 + 1122 WP_002887282.1 cupin domain-containing protein -
IMY63_RS22970 4670037..4670570 - 534 WP_002887280.1 GNAT family N-acetyltransferase Toxin
IMY63_RS22975 4670581..4670847 - 267 WP_002887278.1 DUF1778 domain-containing protein Antitoxin
IMY63_RS22980 4670950..4672383 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
IMY63_RS22985 4672373..4673056 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
IMY63_RS22990 4673228..4674613 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
IMY63_RS22995 4674631..4674975 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T177612 WP_002887280.1 NZ_CP063147:c4670570-4670037 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T177612 NZ_CP083595:c1132534-1132262 [Macrococcus armenti]
ATGCCTAAGAAAAAGATACTATTTTATTCAGGTGGTTTTGAAGATTATACGTATTGGCAAACTAACGATAAAACTGTATT
AAAGAAAATAAATAAACTAATAAAAAGTATTATGATTGATGGTGCAAATGAAGGTATAGGTAAGCCAGAAAAATTATTAG
GGAACTATACAGGTTGCTATAGCAGAAGGATCACTCATGAACATAGGCTCGTATATAAGATAGAAGATGATTCAATATGT
ATTTTACAATGTCGTTTTCATTATAAAAGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT177612 WP_002887278.1 NZ_CP063147:c4670847-4670581 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT177612 NZ_CP083595:c1132784-1132527 [Macrococcus armenti]
ATGAAAGTCACAACTTATTCTAATGCAAGATCAAATTTTAGAAAAATAATAGATATTGTTAATGAAGACTGTGAACCTTA
CACAATCACAACAAATACGCATAATGCCGTGATATTATCTGAACAAGATTATAATAGTATGATTGAAACACTTTACTTAC
AGAGTACACCAGCGAATGCTGAAAGATTACAAAAAGCGATTGATGAATCAATTGATAAAAATAACTTACTTCAAGTTGAG
ATTGATTTAGATGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLZ1

References