Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4057348..4057967 Replicon chromosome
Accession NZ_CP063147
Organism Klebsiella pneumoniae strain KP19-3088

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag IMY63_RS20025 Protein ID WP_002892050.1
Coordinates 4057749..4057967 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag IMY63_RS20020 Protein ID WP_002892066.1
Coordinates 4057348..4057722 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMY63_RS20010 4052500..4053693 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IMY63_RS20015 4053716..4056862 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
IMY63_RS20020 4057348..4057722 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
IMY63_RS20025 4057749..4057967 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
IMY63_RS20030 4058126..4058692 + 567 WP_002892030.1 maltose O-acetyltransferase -
IMY63_RS20035 4058664..4058804 - 141 WP_004147370.1 hypothetical protein -
IMY63_RS20040 4058825..4059295 + 471 WP_002892026.1 YlaC family protein -
IMY63_RS20045 4059270..4060721 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
IMY63_RS20050 4060822..4061520 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
IMY63_RS20055 4061517..4061657 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
IMY63_RS20060 4061657..4061920 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T177611 WP_002892050.1 NZ_CP063147:4057749-4057967 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T177611 NZ_CP083594:c1938817-1938467 [Macrococcus armenti]
ATGAAACGTGGAGATGTTTATTTAGCTGATTTGTCACCGGTAAAGGGATCAGAACAAGGCGGTAAACGCCCTGTTGTCAT
TATTCAGAACAATATAGGTAATAAATATAGCCCAACAGTAATTGTCGCGGCAATTACAGCAAAGATTAACAAAGCAAAGA
TTCCCACCCACGTTGAAATCGGAAAGACGAGTCATCACCTGGAAAAGGATTCGGTAATTCTGTTGGAACAAATAAGAACG
ATAGATAAGAATAGATTGATTGATCATTTAACTGTATTAGATAAAGTGAAGATGAAAGAAGTGGATGTTGCGCTTGCAAT
TAGTCTGGGATTATCAATAGAGAGTGAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT177611 WP_002892066.1 NZ_CP063147:4057348-4057722 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT177611 NZ_CP083594:c1938958-1938818 [Macrococcus armenti]
ATGAGCCAGAAGCTGGAACAAATGCTTATTGAAGGTTATCAATCTATGGCAGAGATTAATTTATCGATTGCATCAGAGCA
TTACATCTTAGAATGTGAAGTAAACGATAACCATCAGACATTAGCACTAGATGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References