Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 4057348..4057967 | Replicon | chromosome |
Accession | NZ_CP063147 | ||
Organism | Klebsiella pneumoniae strain KP19-3088 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | IMY63_RS20025 | Protein ID | WP_002892050.1 |
Coordinates | 4057749..4057967 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | IMY63_RS20020 | Protein ID | WP_002892066.1 |
Coordinates | 4057348..4057722 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IMY63_RS20010 | 4052500..4053693 | + | 1194 | WP_002892072.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
IMY63_RS20015 | 4053716..4056862 | + | 3147 | WP_002892069.1 | multidrug efflux RND transporter permease subunit AcrB | - |
IMY63_RS20020 | 4057348..4057722 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
IMY63_RS20025 | 4057749..4057967 | + | 219 | WP_002892050.1 | hemolysin expression modulator Hha | Toxin |
IMY63_RS20030 | 4058126..4058692 | + | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
IMY63_RS20035 | 4058664..4058804 | - | 141 | WP_004147370.1 | hypothetical protein | - |
IMY63_RS20040 | 4058825..4059295 | + | 471 | WP_002892026.1 | YlaC family protein | - |
IMY63_RS20045 | 4059270..4060721 | - | 1452 | WP_002892023.1 | PLP-dependent aminotransferase family protein | - |
IMY63_RS20050 | 4060822..4061520 | + | 699 | WP_002892021.1 | GNAT family N-acetyltransferase | - |
IMY63_RS20055 | 4061517..4061657 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
IMY63_RS20060 | 4061657..4061920 | - | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T177611 WP_002892050.1 NZ_CP063147:4057749-4057967 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T177611 NZ_CP083594:c1938817-1938467 [Macrococcus armenti]
ATGAAACGTGGAGATGTTTATTTAGCTGATTTGTCACCGGTAAAGGGATCAGAACAAGGCGGTAAACGCCCTGTTGTCAT
TATTCAGAACAATATAGGTAATAAATATAGCCCAACAGTAATTGTCGCGGCAATTACAGCAAAGATTAACAAAGCAAAGA
TTCCCACCCACGTTGAAATCGGAAAGACGAGTCATCACCTGGAAAAGGATTCGGTAATTCTGTTGGAACAAATAAGAACG
ATAGATAAGAATAGATTGATTGATCATTTAACTGTATTAGATAAAGTGAAGATGAAAGAAGTGGATGTTGCGCTTGCAAT
TAGTCTGGGATTATCAATAGAGAGTGAATAG
ATGAAACGTGGAGATGTTTATTTAGCTGATTTGTCACCGGTAAAGGGATCAGAACAAGGCGGTAAACGCCCTGTTGTCAT
TATTCAGAACAATATAGGTAATAAATATAGCCCAACAGTAATTGTCGCGGCAATTACAGCAAAGATTAACAAAGCAAAGA
TTCCCACCCACGTTGAAATCGGAAAGACGAGTCATCACCTGGAAAAGGATTCGGTAATTCTGTTGGAACAAATAAGAACG
ATAGATAAGAATAGATTGATTGATCATTTAACTGTATTAGATAAAGTGAAGATGAAAGAAGTGGATGTTGCGCTTGCAAT
TAGTCTGGGATTATCAATAGAGAGTGAATAG
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT177611 WP_002892066.1 NZ_CP063147:4057348-4057722 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT177611 NZ_CP083594:c1938958-1938818 [Macrococcus armenti]
ATGAGCCAGAAGCTGGAACAAATGCTTATTGAAGGTTATCAATCTATGGCAGAGATTAATTTATCGATTGCATCAGAGCA
TTACATCTTAGAATGTGAAGTAAACGATAACCATCAGACATTAGCACTAGATGGTGAATAA
ATGAGCCAGAAGCTGGAACAAATGCTTATTGAAGGTTATCAATCTATGGCAGAGATTAATTTATCGATTGCATCAGAGCA
TTACATCTTAGAATGTGAAGTAAACGATAACCATCAGACATTAGCACTAGATGGTGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |