Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2710751..2712339 Replicon chromosome
Accession NZ_CP063147
Organism Klebsiella pneumoniae strain KP19-3088

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag IMY63_RS13410 Protein ID WP_004199851.1
Coordinates 2710751..2712073 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag IMY63_RS13415 Protein ID WP_002904790.1
Coordinates 2712073..2712339 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMY63_RS13395 2705816..2708317 + 2502 WP_004199853.1 fimbrial biogenesis outer membrane usher protein -
IMY63_RS13400 2708305..2709309 + 1005 WP_004199852.1 type 1 fimbrial protein -
IMY63_RS13405 2709442..2710734 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
IMY63_RS13410 2710751..2712073 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
IMY63_RS13415 2712073..2712339 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
IMY63_RS13420 2712605..2712931 - 327 WP_002904788.1 hydroxyisourate hydrolase -
IMY63_RS13425 2712928..2713428 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
IMY63_RS13430 2713406..2714785 - 1380 Protein_2627 purine permease -
IMY63_RS13435 2715131..2716285 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
IMY63_RS13440 2716266..2717189 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T177610 WP_004199851.1 NZ_CP063147:c2712073-2710751 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T177610 NZ_CP083592:c1931117-1930767 [Macrococcus armenti]
ATGAAACGTGGAGATGTTTATTTAGCTGATTTGTCACCGGTAAAGGGATCAGAACAAGGCGGTAAACGCCCTGTTGTCAT
TATTCAGAACAATATAGGTAATAAATATAGCCCAACAGTAATTGTCGCGGCAATTACAGCAAAGATTAACAAAGCAAAGA
TTCCCACCCACGTTGAAATCGGAAAGATGAGTCATCACCTGGAAAAGGATTCGGTAATTCTGTTGGAACAAATAAGAACG
ATAGATAAGAATAGATTGATTGATCATTTAACTGTATTAGATAAAGTGAAGATGAAAGAAGTGGATGTTGCGCTTGCAAT
TAGTCTGGGATTATCAATAGAGAGTGAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT177610 WP_002904790.1 NZ_CP063147:c2712339-2712073 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT177610 NZ_CP083592:c1931258-1931118 [Macrococcus armenti]
ATGAGCCAGAAGCTGGAACAAATGCTTATTGAAGGTTATCAATCTATGGCAGAGATTAATTTATCGATTGCATCAGAGCA
TTACATCTTAGAATGTGAAGTAAACGATAACCATCAGACATTAGCACTAGATGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References