Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 413187..413698 Replicon chromosome
Accession NZ_CP063145
Organism Cruoricaptor ignavus strain M1214

Toxin (Protein)


Gene name relE Uniprot ID A0A1M6BJ90
Locus tag IMZ16_RS01875 Protein ID WP_073178066.1
Coordinates 413187..413444 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1M6BJC3
Locus tag IMZ16_RS01880 Protein ID WP_073178064.1
Coordinates 413444..413698 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMZ16_RS01850 408785..410437 - 1653 WP_073178051.1 mercury(II) reductase -
IMZ16_RS01855 410485..411087 - 603 WP_193440256.1 mercuric transport protein MerTP -
IMZ16_RS01860 411084..411458 - 375 WP_193440257.1 metalloregulator ArsR/SmtB family transcription factor -
IMZ16_RS01865 411957..412424 - 468 WP_193440258.1 hypothetical protein -
IMZ16_RS01870 412911..413108 - 198 WP_193440259.1 hypothetical protein -
IMZ16_RS01875 413187..413444 - 258 WP_073178066.1 Txe/YoeB family addiction module toxin Toxin
IMZ16_RS01880 413444..413698 - 255 WP_073178064.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
IMZ16_RS01885 413855..414922 - 1068 WP_193440260.1 nitronate monooxygenase family protein -
IMZ16_RS01890 415208..415393 + 186 WP_193440261.1 hypothetical protein -
IMZ16_RS01895 415781..416050 + 270 WP_193439832.1 transposase -
IMZ16_RS01900 416082..416909 + 828 WP_193439181.1 IS3 family transposase -
IMZ16_RS01905 417402..417629 - 228 WP_193440262.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 397780..417170 19390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10632.08 Da        Isoelectric Point: 8.7763

>T177596 WP_073178066.1 NZ_CP063145:c413444-413187 [Cruoricaptor ignavus]
MRYVFVDESWEDYLYWQKTDKKKLKRINDLLKDISRNPFEGIGKPEPLKHKYSGFWSRRIDDEHRLIYRYEEGEIQIAKC
RFHYD

Download         Length: 258 bp

>T177596 NZ_CP083585:3547494-3547712 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9539.94 Da        Isoelectric Point: 7.0124

>AT177596 WP_073178064.1 NZ_CP063145:c413698-413444 [Cruoricaptor ignavus]
MLIASVSDFRKDIKTYLDKVAKNFETLIISRGKDSGIVVMSLNEYNSLMATNHELSTRANELRLDSAIDKLKSKNSFEKT
LIEE

Download         Length: 255 bp

>AT177596 NZ_CP083585:3547094-3547468 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M6BJ90

Antitoxin

Source ID Structure
AlphaFold DB A0A1M6BJC3

References