Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 972273..972790 Replicon chromosome
Accession NZ_CP063143
Organism Staphylococcus lugdunensis strain IVK28

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag IMZ86_RS04485 Protein ID WP_002461192.1
Coordinates 972440..972790 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag IMZ86_RS04480 Protein ID WP_002461193.1
Coordinates 972273..972443 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMZ86_RS04455 968098..968580 + 483 WP_002492078.1 PH domain-containing protein -
IMZ86_RS04460 968573..970087 + 1515 WP_002492082.1 PH domain-containing protein -
IMZ86_RS04465 970074..970586 + 513 WP_002461197.1 PH domain-containing protein -
IMZ86_RS04470 970598..970990 + 393 WP_002461196.1 holo-ACP synthase -
IMZ86_RS04475 971038..972186 + 1149 WP_002492086.1 alanine racemase -
IMZ86_RS04480 972273..972443 + 171 WP_002461193.1 hypothetical protein Antitoxin
IMZ86_RS04485 972440..972790 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IMZ86_RS04490 973224..974225 + 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
IMZ86_RS04495 974316..974642 + 327 WP_002461190.1 anti-sigma factor antagonist -
IMZ86_RS04500 974644..975123 + 480 WP_002492094.1 anti-sigma B factor RsbW -
IMZ86_RS04505 975098..975868 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T177594 WP_002461192.1 NZ_CP063143:972440-972790 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T177594 NZ_CP083585:c2823592-2823209 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT177594 WP_002461193.1 NZ_CP063143:972273-972443 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT177594 NZ_CP083585:c2824053-2823673 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References