Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 960875..961393 Replicon chromosome
Accession NZ_CP063143
Organism Staphylococcus lugdunensis strain IVK28

Toxin (Protein)


Gene name TsdT Uniprot ID A0A853V532
Locus tag IMZ86_RS04425 Protein ID WP_002492077.1
Coordinates 961181..961393 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A853V130
Locus tag IMZ86_RS04420 Protein ID WP_002492098.1
Coordinates 960875..961168 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMZ86_RS04400 956475..957113 + 639 WP_002492090.1 thiamine phosphate synthase -
IMZ86_RS04405 957203..958078 + 876 WP_002461212.1 membrane protein insertase YidC -
IMZ86_RS04410 958462..959103 - 642 WP_002492092.1 HD domain-containing protein -
IMZ86_RS04415 959225..960709 - 1485 WP_002478972.1 cardiolipin synthase -
IMZ86_RS04420 960875..961168 + 294 WP_002492098.1 copper-sensing transcriptional repressor CsoR Antitoxin
IMZ86_RS04425 961181..961393 + 213 WP_002492077.1 heavy-metal-associated domain-containing protein Toxin
IMZ86_RS04430 961484..961621 + 138 WP_002461206.1 hypothetical protein -
IMZ86_RS04435 962035..963225 - 1191 WP_002461205.1 rod shape-determining protein RodA -
IMZ86_RS04440 963581..964651 + 1071 WP_002461204.1 D-alanine--D-alanine ligase -
IMZ86_RS04445 964669..966027 + 1359 WP_002492089.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-90)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8087.02 Da        Isoelectric Point: 3.9947

>T177593 WP_002492077.1 NZ_CP063143:961181-961393 [Staphylococcus lugdunensis]
VEKRLIYITNVTNEDDLENLRTRLLEMIGVNEVVINFDERAVNVTFETSTNLNALEKEIYDAGYHAIDDL

Download         Length: 213 bp

>T177593 NZ_CP083585:2658122-2658229 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11177.85 Da        Isoelectric Point: 6.6367

>AT177593 WP_002492098.1 NZ_CP063143:960875-961168 [Staphylococcus lugdunensis]
MNEQDHAHHSKIVKANLKSRLNRIEGQVRAINRMVEDDVYCDDVLTQIRATRSALTSVATKLLEHHMKSCIMDKINDGQE
VEAMEELLVTFQKMLKD

Download         Length: 294 bp

>AT177593 NZ_CP083585:c2658069-2658008 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V532

Antitoxin

Source ID Structure
AlphaFold DB A0A853V130

References