Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1815534..1816068 Replicon chromosome
Accession NZ_CP063127
Organism Haemophilus influenzae strain M1C112_1

Toxin (Protein)


Gene name relE Uniprot ID A0A0M1GMI0
Locus tag INP89_RS09075 Protein ID WP_012054909.1
Coordinates 1815778..1816068 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag INP89_RS09070 Protein ID WP_012054910.1
Coordinates 1815534..1815788 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INP89_RS09030 1810769..1810933 + 165 WP_012054917.1 hypothetical protein -
INP89_RS09035 1811001..1811216 + 216 WP_012054916.1 AlpA family phage regulatory protein -
INP89_RS09040 1811197..1811427 + 231 WP_012054915.1 hypothetical protein -
INP89_RS09045 1811487..1812080 + 594 WP_080491705.1 host cell division inhibitor Icd-like protein -
INP89_RS09050 1812073..1812312 + 240 WP_074040131.1 hypothetical protein -
INP89_RS09055 1812309..1812533 + 225 WP_012054913.1 hypothetical protein -
INP89_RS09060 1812542..1812820 + 279 WP_012054912.1 hypothetical protein -
INP89_RS09065 1812830..1815037 + 2208 WP_012054911.1 DUF927 domain-containing protein -
INP89_RS09070 1815534..1815788 + 255 WP_012054910.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
INP89_RS09075 1815778..1816068 + 291 WP_012054909.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INP89_RS09080 1816669..1816992 - 324 WP_005653397.1 ribosome-associated translation inhibitor RaiA -
INP89_RS09085 1817162..1817809 - 648 WP_112083355.1 outer membrane protein assembly factor BamC -
INP89_RS09090 1817921..1818817 - 897 WP_112083356.1 4-hydroxy-tetrahydrodipicolinate synthase -
INP89_RS09095 1818918..1819385 + 468 WP_038439191.1 thioredoxin-dependent thiol peroxidase -
INP89_RS09100 1819554..1820006 + 453 WP_005648856.1 TonB-system energizer ExbB -
INP89_RS09105 1820010..1820453 + 444 WP_005694050.1 TonB system transport protein ExbD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11237.15 Da        Isoelectric Point: 10.4256

>T177592 WP_012054909.1 NZ_CP063127:1815778-1816068 [Haemophilus influenzae]
MTYKLTFSPKAKKEWDKLGDTIKNQFKKKLLERLENPHVPADRLSGFSGVFYKIKLRSVGYRLVYEVIEDKVIVYVLAVG
KRERAEVYTAARDRLN

Download         Length: 291 bp

>T177592 NZ_CP083585:2657586-2657693 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9560.93 Da        Isoelectric Point: 4.1317

>AT177592 WP_012054910.1 NZ_CP063127:1815534-1815788 [Haemophilus influenzae]
MAIHQILTEQAASITDLKRNPMGVMRESENGVIAILNRNQPAFYCLTPEMFAYMQELIEDAELVRIAEERKAEGGFIEVD
FNDL

Download         Length: 255 bp

>AT177592 NZ_CP083585:c2657533-2657472 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M1GMI0

Antitoxin

Source ID Structure

References