177591

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1620113..1620591 Replicon chromosome
Accession NZ_CP063127
Organism Haemophilus influenzae strain M1C112_1

Toxin (Protein)


Gene name VapD Uniprot ID A0A0H3PEZ5
Locus tag INP89_RS08020 Protein ID WP_005656500.1
Coordinates 1620313..1620591 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0K9KX05
Locus tag INP89_RS08015 Protein ID WP_012055040.1
Coordinates 1620113..1620304 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INP89_RS07995 1616340..1617320 + 981 WP_197541616.1 DNA polymerase III subunit delta' -
INP89_RS08000 1617359..1618141 + 783 WP_012055041.1 YchF/TatD family DNA exonuclease -
INP89_RS08005 1618168..1618692 + 525 WP_005669286.1 DUF1523 family protein -
INP89_RS08010 1618743..1620041 + 1299 WP_074040071.1 hemolysin family protein -
INP89_RS08015 1620113..1620304 + 192 WP_012055040.1 DUF5397 family protein Antitoxin
INP89_RS08020 1620313..1620591 + 279 WP_005656500.1 virulence-associated protein VapD Toxin
INP89_RS08025 1620684..1621214 + 531 WP_005686915.1 hypothetical protein -
INP89_RS08030 1621286..1622785 + 1500 WP_012055039.1 fused PTS fructose transporter subunit IIA/HPr protein -
INP89_RS08035 1622787..1623728 + 942 WP_012055038.1 1-phosphofructokinase -
INP89_RS08040 1623730..1625400 + 1671 WP_012055037.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.09 Da        Isoelectric Point: 5.7408

>T177591 WP_005656500.1 NZ_CP063127:1620313-1620591 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T177591 NZ_CP083585:2657050-2657157 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7018.97 Da        Isoelectric Point: 3.9930

>AT177591 WP_012055040.1 NZ_CP063127:1620113-1620304 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDALVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT177591 NZ_CP083585:c2656997-2656936 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3PEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9KX05

References