Detailed information of TA system TA177590

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1418047..1418695
• Replicon: chromosome
• Accession: NZ_CP063127
• Organism: Haemophilus influenzae strain M1C112_1

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A0Y7JUP0
• Locus tag: INP89_RS06980
• Protein ID: WP_005694481.1
• Coordinates: 1418047..1418406 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: INP89_RS06985
• Protein ID: WP_005650837.1
• Coordinates: 1418399..1418695 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INP89_RS06960	1414553..1414720	+	168	WP_197541723.1	PT domain-containing protein	-
INP89_RS06965	1415284..1415445	+	162	WP_197541596.1	hypothetical protein	-
INP89_RS06970	1416990..1417172	+	183	WP_197541724.1	TonB-dependent receptor	-
INP89_RS06975	1417205..1417522	+	318	WP_197541597.1	hypothetical protein	-
INP89_RS06980	1418047..1418406	+	360	WP_005694481.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
INP89_RS06985	1418399..1418695	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
INP89_RS06990	1418856..1420772	+	1917	WP_012055157.1	ABC transporter ATP-binding protein	-
INP89_RS06995	1420782..1421318	+	537	WP_197541598.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
INP89_RS07000	1421334..1421885	+	552	WP_012055155.1	threonylcarbamoyl-AMP synthase	-
INP89_RS07005	1421889..1422695	+	807	WP_012055154.1	shikimate dehydrogenase	-
INP89_RS07010	1422707..1423465	+	759	WP_012055153.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (36-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 14321.67 Da
• Isoelectric Point: 10.1408

>T177590 WP_005694481.1 NZ_CP063127:1418047-1418406 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFARLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Nucleotide

• Length: 360 bp

>T177590 NZ_CP083585:c2452903-2452727 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGATGCGCAGTGTCATGCCGCGTCCCCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT177590 WP_005650837.1 NZ_CP063127:1418399-1418695 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT177590 NZ_CP083585:c2452681-2452265 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y7JUP0