Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 1191069..1192256 Replicon chromosome
Accession NZ_CP063087
Organism Helicobacter winghamensis strain 2015D-0170

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag A0Z60_RS05985 Protein ID WP_197550013.1
Coordinates 1191489..1192256 (+) Length 256 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag A0Z60_RS05980 Protein ID WP_197550012.1
Coordinates 1191069..1191485 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A0Z60_RS05965 1186563..1187369 - 807 WP_197550010.1 3-methyl-2-oxobutanoate hydroxymethyltransferase -
A0Z60_RS05975 1187873..1190956 - 3084 WP_197550011.1 type I restriction endonuclease subunit R -
A0Z60_RS05980 1191069..1191485 + 417 WP_197550012.1 DUF4065 domain-containing protein Antitoxin
A0Z60_RS05985 1191489..1192256 + 768 WP_197550013.1 hypothetical protein Toxin
A0Z60_RS05990 1192236..1193546 - 1311 WP_197550014.1 restriction endonuclease subunit S -
A0Z60_RS05995 1193543..1195048 - 1506 Protein_1165 SAM-dependent DNA methyltransferase -
A0Z60_RS06000 1195245..1196075 + 831 WP_197550015.1 hypothetical protein -
A0Z60_RS06005 1196315..1197241 + 927 WP_197550660.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(23-117)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29472.93 Da        Isoelectric Point: 6.4894

>T177586 WP_197550013.1 NZ_CP063087:1191489-1192256 [Helicobacter winghamensis]
MSSSNDILDDKIKNIIAKLCESRQFDPNEAECIIKDLKNIYQDGYRHKYSQITKIILEKSDSEEDGLAILGQNLRTLEES
IQKSSTDDELNRVKYKLDKLLDHINLEILRLGDSSKNFDKLHSKSNELQDKFNNLQETSSKIEDKLNKQQTQYITILGIF
ASIVLAFVGGFTFSTSALSNIDKASIYRLVFVLSFIALFFGNILFALFRFLSKFNTHISDESKKWYQQPILYFNAVAMLI
MMLDCIAYFLFKYCL

Download         Length: 768 bp

>T177586 NZ_CP083585:998533-998868 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 16108.14 Da        Isoelectric Point: 5.8343

>AT177586 WP_197550012.1 NZ_CP063087:1191069-1191485 [Helicobacter winghamensis]
MKASDVAKYILKNSSKRLSNLELQKTLYFAEVDFIKEHKKSLIDDNFEAWQFGPVVRDVYMEYRDYGANSIDVPDNQGEL
DLSDTERETIAKTIKQCNSKSYWDLVGETHREGGAWYKTYQKGQKKIIDKELIKKEAE

Download         Length: 417 bp

>AT177586 NZ_CP083585:998285-998533 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References