Detailed information of TA system TA177586

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1191069..1192256
• Replicon: chromosome
• Accession: NZ_CP063087
• Organism: Helicobacter winghamensis strain 2015D-0170

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: A0Z60_RS05985
• Protein ID: WP_197550013.1
• Coordinates: 1191489..1192256 (+)
• Length: 256 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: A0Z60_RS05980
• Protein ID: WP_197550012.1
• Coordinates: 1191069..1191485 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A0Z60_RS05965	1186563..1187369	-	807	WP_197550010.1	3-methyl-2-oxobutanoate hydroxymethyltransferase	-
A0Z60_RS05975	1187873..1190956	-	3084	WP_197550011.1	type I restriction endonuclease subunit R	-
A0Z60_RS05980	1191069..1191485	+	417	WP_197550012.1	DUF4065 domain-containing protein	Antitoxin
A0Z60_RS05985	1191489..1192256	+	768	WP_197550013.1	hypothetical protein	Toxin
A0Z60_RS05990	1192236..1193546	-	1311	WP_197550014.1	restriction endonuclease subunit S	-
A0Z60_RS05995	1193543..1195048	-	1506	Protein_1165	SAM-dependent DNA methyltransferase	-
A0Z60_RS06000	1195245..1196075	+	831	WP_197550015.1	hypothetical protein	-
A0Z60_RS06005	1196315..1197241	+	927	WP_197550660.1	methyl-accepting chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (23-117)

Sequences

Toxin

Protein

• Length: 256 a.a.
• Molecular weight: 29472.93 Da
• Isoelectric Point: 6.4894

>T177586 WP_197550013.1 NZ_CP063087:1191489-1192256 [Helicobacter winghamensis]
MSSSNDILDDKIKNIIAKLCESRQFDPNEAECIIKDLKNIYQDGYRHKYSQITKIILEKSDSEEDGLAILGQNLRTLEES
IQKSSTDDELNRVKYKLDKLLDHINLEILRLGDSSKNFDKLHSKSNELQDKFNNLQETSSKIEDKLNKQQTQYITILGIF
ASIVLAFVGGFTFSTSALSNIDKASIYRLVFVLSFIALFFGNILFALFRFLSKFNTHISDESKKWYQQPILYFNAVAMLI
MMLDCIAYFLFKYCL

Nucleotide

• Length: 768 bp

>T177586 NZ_CP083585:998533-998868 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 16108.14 Da
• Isoelectric Point: 5.8343

>AT177586 WP_197550012.1 NZ_CP063087:1191069-1191485 [Helicobacter winghamensis]
MKASDVAKYILKNSSKRLSNLELQKTLYFAEVDFIKEHKKSLIDDNFEAWQFGPVVRDVYMEYRDYGANSIDVPDNQGEL
DLSDTERETIAKTIKQCNSKSYWDLVGETHREGGAWYKTYQKGQKKIIDKELIKKEAE

Nucleotide

• Length: 417 bp

>AT177586 NZ_CP083585:998285-998533 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA