Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-virA/YafQ(toxin)
Location 621177..621738 Replicon chromosome
Accession NZ_CP063087
Organism Helicobacter winghamensis strain 2015D-0170

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag A0Z60_RS03080 Protein ID WP_197550447.1
Coordinates 621177..621452 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name virA Uniprot ID -
Locus tag A0Z60_RS03085 Protein ID WP_101312996.1
Coordinates 621445..621738 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A0Z60_RS03055 616426..616881 - 456 WP_006802389.1 nicotinate phosphoribosyltransferase -
A0Z60_RS03060 616896..617948 - 1053 WP_197550445.1 aminofutalosine synthase MqnE -
A0Z60_RS03065 618109..618645 + 537 WP_197550446.1 PAS domain-containing protein -
A0Z60_RS03070 618642..620018 + 1377 WP_101312997.1 chemotaxis protein -
A0Z60_RS03075 620220..620465 - 246 WP_006802385.1 hypothetical protein -
A0Z60_RS03080 621177..621452 - 276 WP_197550447.1 type II toxin-antitoxin system YafQ family toxin Toxin
A0Z60_RS03085 621445..621738 - 294 WP_101312996.1 hypothetical protein Antitoxin
A0Z60_RS03090 621748..622218 - 471 WP_006802382.1 hypothetical protein -
A0Z60_RS03095 622374..623633 + 1260 WP_197550448.1 hypothetical protein -
A0Z60_RS03100 623630..624628 + 999 WP_197550449.1 hypothetical protein -
A0Z60_RS03105 624672..625391 + 720 WP_197550450.1 conjugal transfer protein TrbM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11150.95 Da        Isoelectric Point: 9.6419

>T177585 WP_197550447.1 NZ_CP063087:c621452-621177 [Helicobacter winghamensis]
MRKQIFQNSFKKDLKLVRKQNWDMIKIKQCVEDLANLDILPAHYEAHSLKGDFKDFRECHIFGDLVLIYKRDDKEVNYYR
IGRHQDLFKKY

Download         Length: 276 bp

>T177585 NZ_CP083585:871320-871727 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATAATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11361.11 Da        Isoelectric Point: 8.3665

>AT177585 WP_101312996.1 NZ_CP063087:c621738-621445 [Helicobacter winghamensis]
MFDYAKYENASSKELFNALTLVEKRTQKLTLQLKENKEAFKFLKMKLKKSLSNKKLKKVEEPTEDTKLILSKNEPLDYNN
FDDLLESVDLELKAENA

Download         Length: 294 bp

>AT177585 NZ_CP083585:871073-871339 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References