Detailed information of TA system TA177584

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 383027..383640
• Replicon: chromosome
• Accession: NZ_CP063086
• Organism: Helicobacter cinaedi strain 2017D-0197

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HW245_RS01960
• Protein ID: WP_104716832.1
• Coordinates: 383239..383640 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: I7HE84
• Locus tag: HW245_RS01955
• Protein ID: WP_002957229.1
• Coordinates: 383027..383251 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HW245_RS01930	378272..379375	-	1104	WP_104716835.1	hypothetical protein	-
HW245_RS01935	379296..379649	-	354	WP_104716834.1	glycosyltransferase family 2 protein	-
HW245_RS01940	379717..381087	-	1371	WP_104716833.1	U32 family peptidase	-
HW245_RS01945	381136..381810	-	675	WP_002957227.1	hypothetical protein	-
HW245_RS01950	381953..382864	-	912	WP_104716839.1	WYL domain-containing protein	-
HW245_RS01955	383027..383251	+	225	WP_002957229.1	hypothetical protein	Antitoxin
HW245_RS01960	383239..383640	+	402	WP_104716832.1	type II toxin-antitoxin system VapC family toxin	Toxin
HW245_RS01965	383842..384214	+	373	Protein_379	hypothetical protein	-
HW245_RS01970	384289..384477	+	189	WP_104716838.1	hypothetical protein	-
HW245_RS01975	384512..384709	+	198	WP_002957234.1	hypothetical protein	-
HW245_RS01980	384625..384831	+	207	WP_002957235.1	hypothetical protein	-
HW245_RS01985	384865..385026	+	162	WP_165816576.1	hypothetical protein	-
HW245_RS01990	385026..386687	+	1662	WP_104716831.1	DUF262 domain-containing HNH endonuclease family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15265.83 Da
• Isoelectric Point: 9.2314

>T177584 WP_104716832.1 NZ_CP063086:383239-383640 [Helicobacter cinaedi]
MAKIMLDTNICIYIINNKPQYIKDRFLQYRIGDIAISSISVAELYFGVEKSQYKEANTNALNTFLTHLKVIDFAHKEALT
YAKIRADLEYKKSLIGAMDMLISAVALANDLTLITNNTKEFQRVKNLKIENWV

Nucleotide

• Length: 402 bp

>T177584 NZ_CP083585:c767037-766660 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTGTC
CCGCCTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGGCCAGCCCCGGTTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8508.80 Da
• Isoelectric Point: 9.9129

>AT177584 WP_002957229.1 NZ_CP063086:383027-383251 [Helicobacter cinaedi]
MKAKVFKSGNSLAIRLPKALNLTKDCEFNIKQINNNIVLTPANSNWDSLFSAIDSFKGEIKRDELILQDREWQK

Nucleotide

• Length: 225 bp

>AT177584 NZ_CP083585:c767494-767126 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGACGACAATCGCGGCCGCCCCTGGTGGGGACTGCCCTGTACCGTGAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAAGCAACCAGTTACATTACCTTGCCAACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGACCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAATTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A809NJV2