Detailed information of TA system TA177583

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 23440..24520
• Replicon: plasmid pD7095-1
• Accession: NZ_CP063082
• Organism: Helicobacter cinaedi strain D7095

Toxin (Protein)

• Gene name: Fic
• Uniprot ID: -
• Locus tag: HW260_RS11635
• Protein ID: WP_197557865.1
• Coordinates: 23440..24252 (-)
• Length: 271 a.a.

Antitoxin (Protein)

• Gene name: Fti
• Uniprot ID: A0A4U8SJV8
• Locus tag: HW260_RS11640
• Protein ID: WP_052082037.1
• Coordinates: 24257..24520 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HW260_RS11610	18897..19448	-	552	WP_197557860.1	hypothetical protein	-
HW260_RS11615	19553..20428	-	876	WP_197557861.1	replication initiation protein	-
HW260_RS11620	20884..21843	-	960	WP_197557862.1	toprim domain-containing protein	-
HW260_RS11625	22000..22284	-	285	WP_197557863.1	hypothetical protein	-
HW260_RS11630	22393..23058	-	666	WP_197557864.1	AAA family ATPase	-
HW260_RS11635	23440..24252	-	813	WP_197557865.1	Fic family protein	Toxin
HW260_RS11640	24257..24520	-	264	WP_052082037.1	hypothetical protein	Antitoxin
HW260_RS11645	24544..24747	-	204	WP_197557866.1	hypothetical protein	-
HW260_RS11650	24861..25301	-	441	WP_197557867.1	single-stranded DNA-binding protein	-
HW260_RS11655	25298..27274	-	1977	WP_197557868.1	type IA DNA topoisomerase	-
HW260_RS11660	27271..27804	-	534	WP_138092086.1	thermonuclease family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	virB11	1..27811	27811

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (53-157)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 271 a.a.
• Molecular weight: 31548.86 Da
• Isoelectric Point: 9.9035

>T177583 WP_197557865.1 NZ_CP063082:c24252-23440 [Helicobacter cinaedi]
MWDSDEHLNDFDRFLLETNLVGATSLDELRHRERLLTLKRTQTLKTTHIKRDFSYKHLKAIHKHIFQDVYTWAGQDRYEM
GLYGFMSKGDSTFCKGSFLPKQSKSIFENLKQCSLHEKQRDVDTLAQNLTTFMADLNALHPFREGNGRVQRIFINELAHN
AGFALDLNLIPKNDMIEASIQAMQGDNTELLKLIKTNLYSNTQAKLQRRLDINLNNYGKVSDEKQKQEFLERANAIKEQT
KKFNITLDSKSLQRLERINQVQNKERGRGR

Nucleotide

• Length: 813 bp

>T177583 NZ_CP083585:635374-635688 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9942.13 Da
• Isoelectric Point: 4.2828

>AT177583 WP_052082037.1 NZ_CP063082:c24520-24257 [Helicobacter cinaedi]
MTAQVNVLATNNYPEAHSLEESLAILESYRNNLTETQYKSIRSNICNFAIEDMFANQQDIIELIQIEKGEKTADEIIAQH
KSQWGLL

Nucleotide

• Length: 264 bp

>AT177583 NZ_CP083585:635685-636101 [Escherichia coli]
ATGATTACGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A4U8SJV8