Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1666678..1667291 Replicon chromosome
Accession NZ_CP063081
Organism Helicobacter cinaedi strain D7095

Toxin (Protein)


Gene name vapC Uniprot ID I7GSY6
Locus tag HW260_RS08615 Protein ID WP_002957230.1
Coordinates 1666890..1667291 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID I7HE84
Locus tag HW260_RS08610 Protein ID WP_002957229.1
Coordinates 1666678..1666902 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW260_RS08585 1661790..1662467 + 678 WP_172580125.1 molybdate ABC transporter permease subunit -
HW260_RS08590 1662464..1663363 + 900 WP_002957225.1 ATP-binding cassette domain-containing protein -
HW260_RS08595 1663367..1664740 - 1374 WP_015453250.1 U32 family peptidase -
HW260_RS08600 1664789..1665463 - 675 WP_002957227.1 hypothetical protein -
HW260_RS08605 1665606..1666542 - 937 Protein_1685 WYL domain-containing protein -
HW260_RS08610 1666678..1666902 + 225 WP_002957229.1 hypothetical protein Antitoxin
HW260_RS08615 1666890..1667291 + 402 WP_002957230.1 type II toxin-antitoxin system VapC family toxin Toxin
HW260_RS08620 1667493..1667864 + 372 WP_002957232.1 hypothetical protein -
HW260_RS08625 1667939..1668127 + 189 WP_014666336.1 hypothetical protein -
HW260_RS08630 1668162..1668359 + 198 WP_002957234.1 hypothetical protein -
HW260_RS08635 1668275..1668481 + 207 WP_002957235.1 hypothetical protein -
HW260_RS08640 1668515..1668667 + 153 WP_165817802.1 hypothetical protein -
HW260_RS08645 1668677..1670368 + 1692 WP_002957237.1 DUF262 domain-containing HNH endonuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15266.77 Da        Isoelectric Point: 7.9901

>T177582 WP_002957230.1 NZ_CP063081:1666890-1667291 [Helicobacter cinaedi]
MAKIMLDTNICIYIINNKPQYIKDRFLQYRIGDIAISSISVAELYFGVEKSQYKEANTNALNTFLTHLEVIDFAHKEALT
YAKIRADLEYKKSLIGAMDMLISAVALANDLTLITNNTKEFQRVKNLKIENWV

Download         Length: 402 bp

>T177582 NZ_CP083585:c592722-592258 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTCAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8508.80 Da        Isoelectric Point: 9.9129

>AT177582 WP_002957229.1 NZ_CP063081:1666678-1666902 [Helicobacter cinaedi]
MKAKVFKSGNSLAIRLPKALNLTKDCEFNIKQINNNIVLTPANSNWDSLFSAIDSFKGEIKRDELILQDREWQK

Download         Length: 225 bp

>AT177582 NZ_CP083585:c593057-592722 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I7GSY6

Antitoxin

Source ID Structure
AlphaFold DB A0A809NJV2

References