Detailed information of TA system TA177581

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazE-Fic/MazF(toxin)
• Location: 405558..406614
• Replicon: chromosome
• Accession: NZ_CP063081
• Organism: Helicobacter cinaedi strain D7095

Toxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: HW260_RS02240
• Protein ID: WP_014667079.1
• Coordinates: 405558..405869 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: Fic
• Uniprot ID: -
• Locus tag: HW260_RS02245
• Protein ID: WP_002955285.1
• Coordinates: 405892..406614 (+)
• Length: 241 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HW260_RS02205	400826..401197	-	372	WP_015453716.1	DUF5131 family protein	-
HW260_RS02210	401425..401883	+	459	WP_015453715.1	hypothetical protein	-
HW260_RS02215	401915..403084	+	1170	WP_002955290.1	hypothetical protein	-
HW260_RS02220	403385..404137	+	753	WP_015453714.1	helicase C-terminal domain-containing protein	-
HW260_RS02225	404179..404574	+	396	WP_002955289.1	hypothetical protein	-
HW260_RS02230	404519..405223	+	705	WP_002955288.1	hypothetical protein	-
HW260_RS02235	405295..405555	+	261	WP_002955287.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
HW260_RS02240	405558..405869	+	312	WP_014667079.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HW260_RS02245	405892..406614	+	723	WP_002955285.1	Fic family protein	Antitoxin
HW260_RS02250	406630..408474	+	1845	WP_002955284.1	hypothetical protein	-
HW260_RS02255	408455..409614	+	1160	Protein_437	transcriptional regulator	-
HW260_RS02260	409730..410095	+	366	WP_002955281.1	hypothetical protein	-
HW260_RS02265	410101..410481	+	381	WP_002955280.1	Fic family protein	-
HW260_RS02270	410512..411081	+	570	WP_002955279.1	metallophosphoesterase	-
HW260_RS02275	411065..411325	+	261	WP_014667072.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	359549..622159	262610

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-102)

Antitoxin

• Fido domain (74-172)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11979.07 Da
• Isoelectric Point: 8.5080

>T177581 WP_014667079.1 NZ_CP063081:405558-405869 [Helicobacter cinaedi]
MRQFEIFWIDLNLTKGAEISKKRPCVIISPNELNYLQTRLVAPITSKGFDAPFRVNFELEGKKSRILCDQIRCVSIDRFL
NKICDLESNKQEALKNILLEMFA

Nucleotide

• Length: 312 bp

>T177581 NZ_CP083585:c347535-347050 [Escherichia coli]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCGTTAAAAAATCACAGCTCCGGTCTGTCGCGTGTTTACGTTATCTGTATTGCCAATACTCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACGTAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCTTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin

Protein

• Length: 241 a.a.
• Molecular weight: 28290.80 Da
• Isoelectric Point: 7.8535

>AT177581 WP_002955285.1 NZ_CP063081:405892-406614 [Helicobacter cinaedi]
MILDNQEYMLDLCIRMAHHSTAIEGNTLTQDETASIILDNFIPRAIKDREFYEVRNYKYLLPYFIEKLKLNTKIDLELIK
FFHSFIMKDLHEEAGKFKTLENAIIGANFETAKPYLVSSLLKDMCDNLYYKLENSKNDEEKIKAILQSHIHFEKIHPFSD
GNGRIGRLLIAYSCFEHNLTPIVIPKEEKAYYISYLRANKIDDVMIDFIKKIQKEEQQRIEKFKSATLSLKNDLKPKNRK

Nucleotide

• Length: 723 bp

>AT177581 NZ_CP083585:c347804-347526 [Escherichia coli]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGGGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCGTTGATGACGAGCAATACGATGCGTTTCTGGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGCCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA