Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 5063015..5064705 | Replicon | chromosome |
| Accession | NZ_CP063057 | ||
| Organism | Comamonas thiooxydans strain ZDHYF418 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | INP81_RS23280 | Protein ID | WP_054074328.1 |
| Coordinates | 5063827..5064705 (-) | Length | 293 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A4Y8THJ5 |
| Locus tag | INP81_RS23275 | Protein ID | WP_004340321.1 |
| Coordinates | 5063015..5063821 (-) | Length | 269 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| INP81_RS23250 | 5058147..5059004 | - | 858 | WP_012840239.1 | IclR family transcriptional regulator | - |
| INP81_RS23255 | 5059012..5059788 | - | 777 | WP_039050300.1 | SDR family oxidoreductase | - |
| INP81_RS23260 | 5060103..5060861 | - | 759 | WP_054074331.1 | 5'-methylthioadenosine/adenosylhomocysteine nucleosidase | - |
| INP81_RS23265 | 5060993..5061979 | - | 987 | WP_054074330.1 | tripartite tricarboxylate transporter substrate binding protein | - |
| INP81_RS23270 | 5062172..5062972 | - | 801 | WP_054074329.1 | aspartate dehydrogenase | - |
| INP81_RS23275 | 5063015..5063821 | - | 807 | WP_004340321.1 | IclR family transcriptional regulator | Antitoxin |
| INP81_RS23280 | 5063827..5064705 | - | 879 | WP_054074328.1 | alpha/beta hydrolase | Toxin |
| INP81_RS23285 | 5064714..5065247 | - | 534 | WP_003072476.1 | cupin domain-containing protein | - |
| INP81_RS23290 | 5065508..5067184 | - | 1677 | WP_004340316.1 | long-chain-fatty-acid--CoA ligase | - |
| INP81_RS23295 | 5067398..5068462 | - | 1065 | WP_004340312.1 | fructose-bisphosphate aldolase class II | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 293 a.a. Molecular weight: 30628.14 Da Isoelectric Point: 6.3787
>T177575 WP_054074328.1 NZ_CP063057:c5064705-5063827 [Comamonas thiooxydans]
MHEDLLSLKQQLLQTGFPEQLVKLPQKAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALLLGDKARVLAWDAPGYGV
STPLAQSAPADADYAQVLAQSLLVLGVRRCLLVGHSLGALMAARLAVTAAPGLVEQLVLISPAGGYGAPAKAEQQAKVRE
GRLAALAEKGVAGLAAVIDQRLVSSEAPEAVRAWVRWNTARMQPQGYAQAVELLCGSDLAQARGRLGMPVEVWVGEHDVV
TTPAACKSWSELLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS
MHEDLLSLKQQLLQTGFPEQLVKLPQKAQVAWREAGDASSDFAVVLLHGISSGAASWLDVALLLGDKARVLAWDAPGYGV
STPLAQSAPADADYAQVLAQSLLVLGVRRCLLVGHSLGALMAARLAVTAAPGLVEQLVLISPAGGYGAPAKAEQQAKVRE
GRLAALAEKGVAGLAAVIDQRLVSSEAPEAVRAWVRWNTARMQPQGYAQAVELLCGSDLAQARGRLGMPVEVWVGEHDVV
TTPAACKSWSELLGAHYGTLAAAGHASPVEQPMEVAHRLASLLNQSYCPNTS
Download Length: 879 bp
>T177575 NZ_CP083583:562252-562704 [Kovacikia minuta CCNUW1]
ATGACTCGGCTAGACCCGGAAGCGATCGCCCAAAAACTCAGCCGCATGGTTGACCGAATTGACCGACTCAAACTGTTTGA
GGGACTGCCCCTTGAGGAGTATTTACAAGATGACTTGAAGCAAGCCGCGATCGAGCGCCTTTTAGAAGCCATTATTGATG
CGGCTCTCAGCATTAACAAAACCTTGCTCAGGCGTGGAGCAGGCATCATCCCCGCCGACTCGGAATCCTTCAAGAACTTT
GAATCCTTCATTCTGATGGCTGAGAACGGTTTCATTACTGTGGAACTCGCCAACCAACTGGCTCCATCGGGTAGCTTTCG
TAACGTCTTAGCTCACGAGTATGACGATATTGATCCAACCCAAGTTTATAACGCCCTCCAAAAAGCTCTCACCCAGTATC
CCCAATACGTTAAAGCGATTCAAAGCTACCTCGATGCACTGGAAGAGGATTAA
ATGACTCGGCTAGACCCGGAAGCGATCGCCCAAAAACTCAGCCGCATGGTTGACCGAATTGACCGACTCAAACTGTTTGA
GGGACTGCCCCTTGAGGAGTATTTACAAGATGACTTGAAGCAAGCCGCGATCGAGCGCCTTTTAGAAGCCATTATTGATG
CGGCTCTCAGCATTAACAAAACCTTGCTCAGGCGTGGAGCAGGCATCATCCCCGCCGACTCGGAATCCTTCAAGAACTTT
GAATCCTTCATTCTGATGGCTGAGAACGGTTTCATTACTGTGGAACTCGCCAACCAACTGGCTCCATCGGGTAGCTTTCG
TAACGTCTTAGCTCACGAGTATGACGATATTGATCCAACCCAAGTTTATAACGCCCTCCAAAAAGCTCTCACCCAGTATC
CCCAATACGTTAAAGCGATTCAAAGCTACCTCGATGCACTGGAAGAGGATTAA
Antitoxin
Download Length: 269 a.a. Molecular weight: 29259.22 Da Isoelectric Point: 5.3811
>AT177575 WP_004340321.1 NZ_CP063057:c5063821-5063015 [Comamonas thiooxydans]
MSETSEISTNEQDRYTVPALDRGLRLLACFGPAQPVWSAPELARSLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNIDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGRVVAGLAMAIPFTELGPEK
TQLWVQKVQQAAETLSAHLRQQHPDHLR
MSETSEISTNEQDRYTVPALDRGLRLLACFGPAQPVWSAPELARSLELPRSTVFRMLTTLENSGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQALCDELGMTSNLALRDGTSVVYVARVTPSGAFQGAVRVGSRLPAHATVLGRALLHDMDG
AQLRSVFGGEELPQFSESTPRNIDELLRLLAEDRERGYAMGEGFYEPGVSSIAAPVRAADGRVVAGLAMAIPFTELGPEK
TQLWVQKVQQAAETLSAHLRQQHPDHLR
Download Length: 807 bp
>AT177575 NZ_CP083583:561818-562255 [Kovacikia minuta CCNUW1]
GTGACTACTCTTGACTCCCTCAAAGCCGCATTTTCAACCCTGGCATCTACCCATTGTGATCTCAAACTTCTCGTCCTATT
CGGCTCCAGAACCAGAGGCGAAGCAGATCCTAGCAGCGATTGGGACTTTGCCTTTCTGTTAGAGCCAGATCGCCCCGTTG
AACTCAAACCCTTCTGGTTTCCTGGCTCCAACCTGTTGGGTACACTCTGCAATCTACTGCATGTGTCCGAAGACGCGATC
GACCTTGTAGACCTCAGTACCTGTTCAGAGATTACTGCCCACTTTGTTGCCCGTGATGGGCAAGTGATCTATGAAAAGAT
AGCCGGAGAATTTGCCCAATTTCAAGGGCGTGCTCTCAAAACCAAGGCTGAACTAAAACAGTATCGCCATGCCCAGCGGG
AAAAGGTGCTTCAAACACTGGAAAGGTGGGGAGTATGA
GTGACTACTCTTGACTCCCTCAAAGCCGCATTTTCAACCCTGGCATCTACCCATTGTGATCTCAAACTTCTCGTCCTATT
CGGCTCCAGAACCAGAGGCGAAGCAGATCCTAGCAGCGATTGGGACTTTGCCTTTCTGTTAGAGCCAGATCGCCCCGTTG
AACTCAAACCCTTCTGGTTTCCTGGCTCCAACCTGTTGGGTACACTCTGCAATCTACTGCATGTGTCCGAAGACGCGATC
GACCTTGTAGACCTCAGTACCTGTTCAGAGATTACTGCCCACTTTGTTGCCCGTGATGGGCAAGTGATCTATGAAAAGAT
AGCCGGAGAATTTGCCCAATTTCAAGGGCGTGCTCTCAAAACCAAGGCTGAACTAAAACAGTATCGCCATGCCCAGCGGG
AAAAGGTGCTTCAAACACTGGAAAGGTGGGGAGTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|