Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2474590..2476172 Replicon chromosome
Accession NZ_CP063056
Organism Rodentibacter sp. DSM 111151

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag IHV77_RS11715 Protein ID WP_194812113.1
Coordinates 2474590..2475870 (-) Length 427 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IHV77_RS11720 Protein ID WP_194812114.1
Coordinates 2475870..2476172 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHV77_RS11695 2470871..2471872 - 1002 WP_194812109.1 anthranilate phosphoribosyltransferase -
IHV77_RS11700 2471919..2472305 - 387 WP_194812110.1 tautomerase family protein -
IHV77_RS11705 2472370..2472951 - 582 WP_194812111.1 aminodeoxychorismate/anthranilate synthase component II -
IHV77_RS11710 2472962..2474509 - 1548 WP_194812112.1 anthranilate synthase component I -
IHV77_RS11715 2474590..2475870 - 1281 WP_194812113.1 type II toxin-antitoxin system HipA family toxin Toxin
IHV77_RS11720 2475870..2476172 - 303 WP_194812114.1 helix-turn-helix domain-containing protein Antitoxin
IHV77_RS11725 2476317..2476901 - 585 WP_194812115.1 NAD(P)H-dependent oxidoreductase -
IHV77_RS11730 2477173..2479104 + 1932 WP_194812116.1 threonine--tRNA ligase -
IHV77_RS11735 2479300..2479671 + 372 WP_194812117.1 YgiW/YdeI family stress tolerance OB fold protein -
IHV77_RS11740 2479731..2480399 + 669 WP_194812118.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(148-392)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 427 a.a.        Molecular weight: 49056.74 Da        Isoelectric Point: 8.4380

>T177571 WP_194812113.1 NZ_CP063056:c2475870-2474590 [Rodentibacter sp. DSM 111151]
MDNSILNVAMNGILVGWWRRLKNGATEFQYAEKWLSSVRSRPISLSLPLSSKIYRGDEVYNFFDNLLPDNEHIRSRIQQR
FQTNTKTPFDLLSAIGQDCVGAIQLYQHNTDFVKTVYAEPLSEFEIENTLKNYRTFPLGMEQEENFRISIAGAQEKTALL
NYNGQWMRPLYTTPTSHIFKLPIGMVAQNQLDLSNSCENEWLCLRIMQVLGLKVPFSAIEHFGEIKTLIVERFDRRWSED
RKWLIRLPQEDMCQALNTAPARKYESDGGPGILQIMQLLNGSANPNEDRKQFFKAQIVFWLLCAIDGHAKNFSIFLEPKG
HYRLTPFYDVISAYPLIKAQGLAKQKVKMAMAWYGENKHYLWDKIQLRHIFATAKLVGLSKTVVEDILQEILTCLPKIDL
IAISHLPNEVSEPILVGLKKQAQKIL

Download         Length: 1281 bp

>T177571 NZ_CP083580:c1451047-1450301 [Bacillus sp. PM8313]
ATGCTGCTTTTTTATCAATTCTCAGTTTGGGTTATCGTTCTGGCTTTGGCTCTGTACGTTTTTGCCGTGTGGCGCTTTGA
AAAAAAGATGAAAGAAAAAACGATTGCCATCCGGAAAACCTGGTATCTCCTTTATGTAATCGGCGCCGTGATTTACTGGA
CGTACAATCCGCAGTCCCTTTTTACAGACCCGCTTCATTATCTGATCGTCGCCGTTTTTTTCACGCTGACCGATGCATTT
ATTTTCTTAAACGCCTACTTTAAAAAACTGGGCAGCAATGAACTGGCGACAGACACAAGAGAGCTGCTCGAAGAAAACAA
CGACCTGCTTCACACCTATCAAAACAGGCTGAAAACGTTCCAATACCTATTGAAAAACGAACCGATTCACATCTATTATG
GAGATATAGAAGCTTATGCAGAAGGCATTGAAAAACTCATTAAACGGTTTGCCGAAAAAATGAATATATCTGCCTCACTC
TGTGAATATAATTCAGAGCAGAGCAAAGATCATTTGCTTGAACACATGGAAAACCGTTTCGCTGTTCAGGAAAAGCTGGA
GCGAAAAGATGTATATTACGAAGAAAACGGAAAAATGGTCCTGATTCCATTTTCTATCCATGAATACGACTATGTCATGA
AACTGACTTCCGAGGACCTTGTCACTGAATTTGATTATCTTCTGTTTACTTCTTTAACGAGCATCTATGATCTCCTGCTA
CCATACGAAGAGGAAGGTGACGAATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11270.73 Da        Isoelectric Point: 5.1100

>AT177571 WP_194812114.1 NZ_CP063056:c2476172-2475870 [Rodentibacter sp. DSM 111151]
MIVTSPKMLSHVIREFRYKDNISQTDIAKQVGIKQATVSNFENTPESTKIETLFKILAALELELVVQPRPTLTKHSSPSS
HNLIEEPSATYNSDDDGEIW

Download         Length: 303 bp

>AT177571 NZ_CP083580:c1450301-1450128 [Bacillus sp. PM8313]
ATGGAGCCGGTTTTTCAGCACGACGAAGACCGTTCAATCAAGCGCGGCGCGTGGAAAGTATTTAAAAAACAATCGAGAAC
AAATATCGCCAAATATGAACTCAGCCCTCATACCGAACGGATTTTCAGACAAAATGCACGGCTGATTGATGAGTATAAAC
GAAAAAATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References