Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1333412..1335030 Replicon chromosome
Accession NZ_CP063056
Organism Rodentibacter sp. DSM 111151

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag IHV77_RS06450 Protein ID WP_194813242.1
Coordinates 1333735..1335030 (-) Length 432 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IHV77_RS06445 Protein ID WP_194811186.1
Coordinates 1333412..1333738 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IHV77_RS06425 1328922..1329890 - 969 WP_194813240.1 ribose ABC transporter permease -
IHV77_RS06430 1329954..1331447 - 1494 WP_194811184.1 ribose ABC transporter ATP-binding protein RbsA -
IHV77_RS06435 1331462..1331881 - 420 WP_194811185.1 D-ribose pyranase -
IHV77_RS06440 1332333..1333052 + 720 WP_194813241.1 lysine/arginine/ornithine ABC transporter substrate-binding protein -
IHV77_RS06445 1333412..1333738 - 327 WP_194811186.1 helix-turn-helix domain-containing protein Antitoxin
IHV77_RS06450 1333735..1335030 - 1296 WP_194813242.1 HipA domain-containing protein Toxin
IHV77_RS06455 1335688..1336326 + 639 WP_194811187.1 SAM-dependent DNA methyltransferase -
IHV77_RS06460 1336323..1337843 + 1521 WP_194811188.1 Eco57I restriction-modification methylase domain-containing protein -
IHV77_RS06465 1337836..1338846 + 1011 WP_194811189.1 FRG domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(157-367)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 49812.71 Da        Isoelectric Point: 4.8937

>T177569 WP_194813242.1 NZ_CP063056:c1335030-1333735 [Rodentibacter sp. DSM 111151]
MNNLTLQIFSESQWVDVAILRFDTDYKLIDIQYENDYVLRFFDEAGSSAISINYPVDFFIERHLDWHTFLDDIVPAGASR
RYWLEALAIQDLSSHQQNYLLLKHGAISPIGNLRIKEALPPEIEKRDFPLEAVLNRQSDFLEYAHQSGAIVGGATGAGGE
APKLLLRRKAQQVWIDNLQTGQENDDYYLVKFPRGKRTPLDCDILRAEFYYYQEIASMGFSTIDTHKMQLEEGDRYPSLW
LPRFDSVQKNEKTDRLAVESVYSMLQKRGGELDQEKTVRQLIQKMVLSGLVMPDIEAFITEWLKRDLLNIAFGNSDNHGR
NTSFLRNETHIWLAPIYDFAPMRADPDGIIRTMTWGRKWEQAGEYDFEGICELFADLASPEILFRSLQQLALDLVDLKAR
LTKRGVPQAILTFPAIGFDYLPEKLQRWKLL

Download         Length: 1296 bp

>T177569 NZ_CP083576:c19959-19633 [Xanthomonas phaseoli pv. manihotis]
ATGATGCGGGGTGACTTTGTGACCATCGCCATGCAAGGCGACTTCGGAAAACCACGGCCCGCTCTGGTCATCCAGGCCAA
CCAGTTTGACGAACACACCACCGTGACGGTGCTGCCGGTGACAAGCACGCTTGTTGCTGCGCCGCTGCTGCGCATTACGG
TTCATCCAAGTACCGACAATGGTTTGCAGAAGCCGTCTCAGGTGATGGTGGACAAGGCCATGACCGTGAAGCGTGACAAG
GTAGGTCGAGCCTTTGGGCGCGTAGACGCTGATGCGTTGGTGGAAATTGAGCGCTGCCTGGCCGTGTTCTTGGGCATCGC
TAAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12243.47 Da        Isoelectric Point: 10.6786

>AT177569 WP_194811186.1 NZ_CP063056:c1333738-1333412 [Rodentibacter sp. DSM 111151]
MTARKKGQKAQPIERTKMRNAILKQLLQGKITQGQALRKLRVEVLGISQERYCQLVKVSRLTLSEIENDKGNYSVETLNQ
IFRPMGLEMGVIPIHKPLLSELLTSGEI

Download         Length: 327 bp

>AT177569 NZ_CP083576:c20126-19956 [Xanthomonas phaseoli pv. manihotis]
ATGGCAGGGCTGCGTCCGGTGCAAATTTGGGTGCCAGACACGCGGCGGCCTGACTTCGCCGAGGAATGCCGCCGTCAGTG
TCGTCTTGCTGCACAAGCGGACATGGCGGACACCGACATGCAGCGCTTCATGGATGAGGCGCTAGCAGACATGGATGGCT
GGACGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References