Detailed information of TA system TA177568

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 551138..551790
• Replicon: chromosome
• Accession: NZ_CP063056
• Organism: Rodentibacter sp. DSM 111151

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: IHV77_RS02755
• Protein ID: WP_194812632.1
• Coordinates: 551138..551356 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IHV77_RS02760
• Protein ID: WP_194812633.1
• Coordinates: 551389..551790 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IHV77_RS02710	546172..546420	-	249	WP_194812623.1	hypothetical protein	-
IHV77_RS02715	546510..546881	+	372	WP_194812624.1	hypothetical protein	-
IHV77_RS02720	546878..547075	+	198	WP_194812625.1	hypothetical protein	-
IHV77_RS02725	547086..547283	+	198	WP_194812626.1	hypothetical protein	-
IHV77_RS02730	547295..547567	+	273	WP_194812627.1	hypothetical protein	-
IHV77_RS02735	547619..547882	+	264	WP_194812628.1	hypothetical protein	-
IHV77_RS02740	547886..550210	+	2325	WP_194812629.1	replication endonuclease	-
IHV77_RS02745	550223..550546	+	324	WP_194812630.1	hypothetical protein	-
IHV77_RS02750	550556..551071	+	516	WP_194812631.1	phage N-6-adenine-methyltransferase	-
IHV77_RS02755	551138..551356	+	219	WP_194812632.1	type II toxin-antitoxin system HicA family toxin	Toxin
IHV77_RS02760	551389..551790	+	402	WP_194812633.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IHV77_RS02765	551802..552077	-	276	WP_194812634.1	ogr/Delta-like zinc finger family protein	-
IHV77_RS02770	552157..553194	-	1038	WP_194812635.1	phage portal protein	-
IHV77_RS02775	553184..555004	-	1821	WP_194812636.1	terminase ATPase subunit family protein	-
IHV77_RS02780	555207..556064	+	858	WP_194812637.1	GPO family capsid scaffolding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	541023..573616	32593

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (18-72)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8070.27 Da
• Isoelectric Point: 10.1721

>T177568 WP_194812632.1 NZ_CP063056:551138-551356 [Rodentibacter sp. DSM 111151]
VGIIPTIERQDGEKVDSKTAIKMIEADGWYLDRVKGSHHQYKHPTKSGTVTIPHPRKDLGHLEKSIKKQAGL

Nucleotide

• Length: 219 bp

>T177568 NZ_CP083575:c4961264-4961151 [Xanthomonas phaseoli pv. manihotis]
TTGAAGGGCGAGCGGCGCGGCCAGTACCGCATCCGGATCAACGATCGATGGCGCATCTGCGTCCGATGGATGGAAGGCGA
TGTGGTCCAGGTCGAAATCATCGATTACCACTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14789.96 Da
• Isoelectric Point: 4.5095

>AT177568 WP_194812633.1 NZ_CP063056:551389-551790 [Rodentibacter sp. DSM 111151]
MLYPICMEKVSDGYVVSVPDVPGCFSAGDNMEEAILNTKEAIAFHIEGMLEDGEELPKSKPAEQYINDPEYHGFIVTVVD
VDLAHLMGKAEKINITLPSLLLHRIDQFVATHPEYKNRSNFLAQLATNKLLTA

Nucleotide

• Length: 402 bp

>AT177568 NZ_CP083575:c4961133-4960843 [Xanthomonas phaseoli pv. manihotis]
ATGACGGTCCTACCCAATATCCACCCTGGCGCAATTCTGCTTGAGGAGTTTCTCCAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGAACCTTCGAGCGCTTCTGGCTTGGCCTGCAGGCCGACGACGAGCTGGAGCAGGCG
CATCGCGCGCTGGGCGACTTGCCGGCGCGGATCAAGCGGCTGGCGGCATGA