Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5635032..5635537 Replicon chromosome
Accession NZ_CP063047
Organism Pseudomonas aeruginosa strain KC-Tt-1

Toxin (Protein)


Gene name parE Uniprot ID A0A3S3VVC5
Locus tag IL983_RS25870 Protein ID WP_031640969.1
Coordinates 5635032..5635313 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag IL983_RS25875 Protein ID WP_003083775.1
Coordinates 5635310..5635537 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IL983_RS25845 5630283..5631632 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
IL983_RS25850 5631681..5632367 + 687 WP_003083762.1 FadR family transcriptional regulator -
IL983_RS25855 5632468..5633202 + 735 WP_003128333.1 GntR family transcriptional regulator -
IL983_RS25860 5633406..5633792 + 387 WP_003083767.1 aegerolysin family protein -
IL983_RS25865 5633824..5634732 - 909 WP_003083769.1 LysR family transcriptional regulator -
IL983_RS25870 5635032..5635313 - 282 WP_031640969.1 type II toxin-antitoxin system toxin ParE Toxin
IL983_RS25875 5635310..5635537 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
IL983_RS25880 5635713..5636336 - 624 WP_019371309.1 hypothetical protein -
IL983_RS25885 5636437..5636937 + 501 WP_003162763.1 LEA type 2 family protein -
IL983_RS25890 5637010..5637351 + 342 WP_003101229.1 alkylphosphonate utilization protein -
IL983_RS25895 5637433..5638860 - 1428 WP_023092260.1 GABA permease -
IL983_RS25900 5639029..5640522 - 1494 WP_034035873.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10475.19 Da        Isoelectric Point: 10.0435

>T177566 WP_031640969.1 NZ_CP063047:c5635313-5635032 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T177566 NZ_CP083575:c4518973-4518839 [Xanthomonas phaseoli pv. manihotis]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT177566 WP_003083775.1 NZ_CP063047:c5635537-5635310 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT177566 NZ_CP083575:c4519200-4519048 [Xanthomonas phaseoli pv. manihotis]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAGTGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S3VVC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References