177551

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4335020..4335851 Replicon chromosome
Accession NZ_CP063046
Organism Escherichia coli strain KC-Dl-1

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag IL980_RS20850 Protein ID WP_000854814.1
Coordinates 4335020..4335394 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A366YXM1
Locus tag IL980_RS20855 Protein ID WP_001518724.1
Coordinates 4335483..4335851 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IL980_RS20810 4330416..4331582 + 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
IL980_RS20815 4331701..4332174 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
IL980_RS20820 4332372..4333430 + 1059 WP_001200894.1 FUSC family protein -
IL980_RS20825 4333602..4333931 + 330 WP_000450409.1 DUF496 family protein -
IL980_RS20830 4334032..4334214 - 183 WP_001016348.1 hypothetical protein -
IL980_RS20835 4334268..4334414 + 147 Protein_4063 transposase domain-containing protein -
IL980_RS20840 4334703..4334816 - 114 WP_001161660.1 DUF957 domain-containing protein -
IL980_RS20845 4334829..4335023 - 195 WP_000988601.1 hypothetical protein -
IL980_RS20850 4335020..4335394 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
IL980_RS20855 4335483..4335851 - 369 WP_001518724.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
IL980_RS20860 4335925..4336146 - 222 WP_000692323.1 DUF987 domain-containing protein -
IL980_RS20865 4336209..4336685 - 477 WP_001186773.1 RadC family protein -
IL980_RS20870 4336701..4337174 - 474 WP_000855075.1 antirestriction protein -
IL980_RS20875 4337437..4338258 - 822 WP_001234710.1 DUF945 domain-containing protein -
IL980_RS20880 4338479..4338889 - 411 WP_000846705.1 hypothetical protein -
IL980_RS20885 4338905..4339558 - 654 WP_001535423.1 hypothetical protein -
IL980_RS20890 4339651..4340828 + 1178 WP_152895938.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T177551 WP_000854814.1 NZ_CP063046:c4335394-4335020 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T177551 NZ_CP083530:c4047235-4047128 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13441.24 Da        Isoelectric Point: 4.7594

>AT177551 WP_001518724.1 NZ_CP063046:c4335851-4335483 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLSSDADAYPLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLACEADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT177551 NZ_CP083530:4047283-4047349 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGGGTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A366YXM1

References