Detailed information of TA system TA177545

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1858332..1859320
• Replicon: chromosome
• Accession: NZ_CP063046
• Organism: Escherichia coli strain KC-Dl-1

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: IL980_RS09040
• Protein ID: WP_014640052.1
• Coordinates: 1858332..1858718 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0J5Z6D5
• Locus tag: IL980_RS09045
• Protein ID: WP_000458584.1
• Coordinates: 1858748..1859320 (-)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IL980_RS08990	1853415..1854239	+	825	WP_000081295.1	YfdQ family protein	-
IL980_RS08995	1854368..1854904	+	537	WP_000008178.1	5'-deoxynucleotidase	-
IL980_RS09000	1854895..1855314	+	420	WP_021549915.1	hypothetical protein	-
IL980_RS09005	1855311..1855610	+	300	WP_021549914.1	hypothetical protein	-
IL980_RS09010	1855612..1856292	+	681	WP_021549913.1	ead/Ea22-like family protein	-
IL980_RS09015	1856294..1856581	+	288	WP_021549912.1	hypothetical protein	-
IL980_RS09020	1856585..1857181	+	597	WP_021549911.1	DUF551 domain-containing protein	-
IL980_RS09025	1857181..1857753	+	573	WP_021549910.1	3'-5' exoribonuclease	-
IL980_RS09030	1857790..1858071	+	282	WP_001093919.1	pyocin activator PrtN family protein	-
IL980_RS09035	1858119..1858292	-	174	WP_021549909.1	hypothetical protein	-
IL980_RS09040	1858332..1858718	-	387	WP_014640052.1	hypothetical protein	Toxin
IL980_RS09045	1858748..1859320	-	573	WP_000458584.1	SocA family protein	Antitoxin
IL980_RS09050	1859792..1860307	+	516	WP_000416264.1	zinc uptake transcriptional repressor Zur	-
IL980_RS09055	1860349..1860558	-	210	WP_001296638.1	CsbD family protein	-
IL980_RS09060	1860674..1861999	-	1326	WP_001296637.1	MATE family efflux transporter DinF	-
IL980_RS09065	1862072..1862680	-	609	WP_000646078.1	transcriptional repressor LexA	-
IL980_RS09070	1862790..1863158	-	369	WP_000002899.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1813753..1860558	46805

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T177545 WP_014640052.1 NZ_CP063046:c1858718-1858332 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T177545 NZ_CP083530:2749780-2750094 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAATC
CAATCCTTTTACTGGTAGATGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCACACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21973.21 Da
• Isoelectric Point: 6.0283

>AT177545 WP_000458584.1 NZ_CP063046:c1859320-1858748 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT177545 NZ_CP083530:2749544-2749777 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Antitoxin

• AlphaFold DB: A0A0J5Z6D5