Detailed information of TA system TA177543

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 1415379..1416199
• Replicon: chromosome
• Accession: NZ_CP063046
• Organism: Escherichia coli strain KC-Dl-1

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: IL980_RS06860
• Protein ID: WP_001054376.1
• Coordinates: 1415379..1415636 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: IL980_RS06865
• Protein ID: WP_001519303.1
• Coordinates: 1415648..1416199 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IL980_RS06840	1410665..1411771	+	1107	WP_001519308.1	N-acetylneuraminate epimerase	-
IL980_RS06845	1411836..1412816	+	981	WP_001519307.1	transposase	-
IL980_RS06850	1413399..1414640	-	1242	Protein_1338	DNA helicase	-
IL980_RS06855	1414703..1415002	+	300	WP_001519304.1	GNAT family N-acetyltransferase	-
IL980_RS06860	1415379..1415636	+	258	WP_001054376.1	hypothetical protein	Toxin
IL980_RS06865	1415648..1416199	+	552	WP_001519303.1	N-acetyltransferase	Antitoxin
IL980_RS06870	1416251..1416412	+	162	WP_001519302.1	hypothetical protein	-
IL980_RS06875	1416449..1416997	+	549	WP_001519301.1	hypothetical protein	-
IL980_RS06880	1417124..1417384	+	261	WP_000084876.1	hypothetical protein	-
IL980_RS06885	1417422..1417538	+	117	Protein_1345	VOC family protein	-
IL980_RS06890	1417783..1418904	+	1122	WP_000010833.1	M42 family metallopeptidase	-
IL980_RS06895	1418901..1419179	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
IL980_RS06900	1419191..1420504	+	1314	WP_001519300.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T177543 WP_001054376.1 NZ_CP063046:1415379-1415636 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T177543 NZ_CP083530:2397708-2397881 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTAGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20463.61 Da
• Isoelectric Point: 6.8758

>AT177543 WP_001519303.1 NZ_CP063046:1415648-1416199 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT177543 NZ_CP083530:2397384-2397680 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: S1PA82